Rabbit Anti-MALT1 Recombinant Antibody (clone R01-5K7) (CAT#: VS3-XY3424)
It is a recombinant rabbit antibody specific for MALT1 (MALT1 paracaspase), which involves in the induction of T helper 17 cells (Th17) differentiation. It specifically reacts with human MALT1. This product has been reported for use in Western Blot, Flow cytometry, Immunocytochemistry or Immunofluorescence. The recommended dilutions of Western Blot, Flow cytometry and Immunofluorescence is 1/500-1/1000, 1/50-1/100 and 1/50-1/200, respectively.
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Subcellular Location
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line U-251 MG
(Immunofluorescent staining of human cell line U-251 MG shows localization to nucleoli fibrillar center.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/48432/if_selected.jpg
(Immunofluorescent staining of human cell line U-251 MG shows localization to nucleoli fibrillar center.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/48432/if_selected.jpg
Figure 2 Colon
(Glandular cells Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/4494/13002_A_9_3.jpg
(Glandular cells Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/4494/13002_A_9_3.jpg
Figure 3 Testis
(Spermatogonia cells Staining: Medium Intensity: Moderate)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/4494/13002_A_6_6.jpg
(Spermatogonia cells Staining: Medium Intensity: Moderate)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/4494/13002_A_6_6.jpg
Figure 4 High expression in lymph node.
(Germinal center cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous Non-germinal center cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/4494/13002_A_9_8.jpg
(Germinal center cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous Non-germinal center cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/4494/13002_A_9_8.jpg
Figure 5 RNA cell line category: Cell line enhanced (RPTEC TERT1)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000172175-MALT1
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000172175-MALT1
Specifications
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human MALT1
- Species Reactivity
- Human
- Clone
- R01-5K7
- Applications
- WB, ICC, IF, FC
- Related Disease
- Mucosa-Associated Lymphoid Type
Product Property
- Clonality
- Monoclonal
- Aggregation
- < 5%
- Format
- Liquid
- Buffer
- PBS (pH 7.4), 150 mM NaCl and 50% glycerol
- Preservative
- 0.02% sodium azide
- Storage
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- WB: 1/500-1/1000
IF: 1/50-1/200
FC: 1/50-1/100
Target
- Alternative Names
- MLT; MLT1; IMD12; PCASP1
- Gene ID
- 10892
- UniProt ID
- Q9UDY8
- Long Name
- MALT1 paracaspase
- Cellular Localization
- Cytoplasm, perinuclear region, Nucleus
- Post Translation Modifications
- Modification sites at PhosphoSitePlus (Q9UDY8)
Modification sites at neXtProt (NX_Q9UDY8)
Glycosylation from GlyGen (Q9UDY8) 1 site, 1 O-linked glycan (1 site)
- Protein Refseq
- XP_054174133.1
- Function
- Protease that enhances BCL10-induced activation: acts via formation of CBM complexes that channel adaptive and innate immune signaling downstream of CARD domain-containing proteins (CARD9, CARD11 and CARD14) to activate NF-kappa-B and MAP kinase p38 pathways which stimulate expression of genes encoding pro-inflammatory cytokines and chemokines (PubMed:11262391, 18264101, 24074955).
Mediates BCL10 cleavage: MALT1-dependent BCL10 cleavage plays an important role in T-cell antigen receptor-induced integrin adhesion.
Recommended Products
Isotype Control
Recommended Dilution Buffer
Secondary Antibody
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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IgG Antibody Products
Rabbit Monoclonal Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1346z | Mouse Anti-MALT1 Recombinant Antibody (clone 23G12) | IF, IHC, WB | Mouse IgG1, κ |
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