PTM™ Rabbit Anti-MAPT (pSer202 / pThr205) Recombinant Antibody (VS13-YC704) (CAT#: VS13-YC704)

• Immunogen
• Synthetic phosphopeptide of human tau (pSer202/pThr205).

• Host Species
• Rabbit

• Type
• Rabbit IgG

• Specificity
• The phosphorylated MAPT (Ser202 / Thr205) of human.

• Species Reactivity
• Human

• Applications
• WB, IP

• Conjugate
• NONE

• Related Disease
• Alzheimer's disease, Pick's disease

• Clonality
• Monoclonal

• Purification
• Protein A purified

• Format
• Liquid

• Concentration
• Please refer to the vial label for the specific concentration.

• Buffer
• TBS (pH 7.4) containing 40% Glycerol and 0.05% BSA.

• Preservative
• 0.05% Sodium azide

• Storage
• Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

• Shipping
• Shipping with ice pack.

• Application Notes
• Western blot (WB): 1/500-1/1000
  Immunoprecipitation (IP): 1/20

• Alternative Names
• Microtubule Associated Protein Tau; G Protein Beta1/Gamma2 Subunit-Interacting Factor 1; Protein Phosphatase 1, Regulatory Subunit 103; Neurofibrillary Tangle Protein; Paired Helical Filament-Tau; PHF-Tau; MAPTL; MTBT1; TAU;

• Gene ID
• 4137

• UniProt ID
• P10636

• Long Name
• Microtubule Associated Protein Tau

• Cellular Localization
• Cell membrane; Cell projection; Cytoplasm; Cytoskeleton; Membrane; Microtubule; Secreted

• Post Translation Modifications
• Phosphorylated

• Protein Refseq
• NP_001116538.2; NP_001116539.1; NP_001190181.1

• Function
• Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity (PubMed:21985311).
  The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both (PubMed:21985311, PubMed:32961270).
  Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization.

Secondary Antibody

• 2ND-059CQ
• Goat Anti-Rabbit IgG (H&L) Antibody

• 2ND-061CQ
• Sheep Anti-Rabbit IgG (H&L) Antibody

Isotype Control

• MOB-208CQ
• Rabbit IgG Isotype Control Antibody