Rabbit Anti-Oprk1 Recombinant Antibody (VS13-YC860) (CAT#: VS13-YC860)
The Rabbit Anti-Oprk1 Recombinant Antibody is specific for mouse and rat Oprk1. Oprk1 encodes an opioid receptor influencing pain perception and opioid response, with variations linked to addiction disorders. The anti-Oprk1 antibody can be used for Western blot (1/500-1/1000), Immunoprecipitation (1/20).
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Subcellular Location
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line AF22
(Immunofluorescent staining of human cell line AF22 shows localization to plasma membrane & cytosol.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/67549/1785_A2_2_selected.jpg
(Immunofluorescent staining of human cell line AF22 shows localization to plasma membrane & cytosol.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/67549/1785_A2_2_selected.jpg
Figure 2 Caudate nucleus
(High expression)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/67549/167027_B_9_7_val_selected.jpg
(High expression)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/67549/167027_B_9_7_val_selected.jpg
Figure 3 Cerebral cortex
(Neuronal cells Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/67549/167027_B_7_5.jpg
(Neuronal cells Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/67549/167027_B_7_5.jpg
Figure 4 Colon
(Peripheral nerve/ganglion Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/67549/167027_A_7_3.jpg
(Peripheral nerve/ganglion Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/67549/167027_A_7_3.jpg
Figure 5 RNA cell line category: Cell line enriched (U-937)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000082556-OPRK1
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000082556-OPRK1
Specifications
- Immunogen
- Recombinant mouse Kappa Opioid Receptor.
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Mouse and Rat Oprk1
- Species Reactivity
- Mouse, Rat
- Applications
- WB, IP
- Conjugate
- NONE
- Related Disease
- Morphine Dependence and Cocaine Dependence
Product Property
- Clonality
- Monoclonal
- Purification
- Affinity Chromatography purified
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- 50 mM Tris-Glycine (pH 7.4) containing 150 mM NaCl, 40% Glycerol and 0.05% BSA.
- Preservative
- 0.01% Sodium azide
- Storage
- Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Shipping with ice pack.
Applications
- Application Notes
- Western blot (WB): 1/500-1/1000
Immunoprecipitation (IP): 1/20
Target
- Alternative Names
- KOR; R21; KOR-1; MSL-1; Oprk2; K-OR-1
- Gene ID
- 18387
- UniProt ID
- P33534
- Long Name
- opioid receptor, kappa 1
- Sequence Similarities
- Belongs to the G-protein coupled receptor 1 family.
- Cellular Localization
- Cell membrane
- Function
- G-protein coupled opioid receptor that functions as a receptor for endogenous alpha-neoendorphins and dynorphins, but has low affinity for beta-endorphins. Also functions as a receptor for various synthetic opioids and for the psychoactive diterpene salvinorin A. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role in the perception of pain. Plays a role in mediating reduced physical activity upon treatment with synthetic opioids. Plays a role in the regulation of salivation in response to synthetic opioids. May play a role in arousal and regulation of autonomic and neuroendocrine functions.
Recommended Products
Secondary Antibody
Isotype Control
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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See other products for "OPRK1"
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IgG Antibody Products
Single Domain Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-2742z | Mouse Anti-OPRK1 Recombinant Antibody (clone 43A12) | ELISA, IHC | Mouse IgG1 |
| VS3-FY1753 | Rabbit Anti-Oprk1 Recombinant Antibody (clone R03-2A5) | WB, IP | Rabbit IgG |
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For Research Use Only. Not For Clinical Use.
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