Rabbit Anti-Oprk1 Recombinant Antibody (clone R03-2A5) (CAT#: VS3-FY1753)

• Immunogen
• Synthetic peptides for mouse Kappa opioid receptors

• Host Species
• Rabbit

• Type
• Rabbit IgG

• Specificity
• Mouse and Rat Oprk1

• Species Reactivity
• Mouse, Rat

• Clone
• R03-2A5

• Applications
• Western Blot, Immunoprecipitation

• MW
• The calculated weight of the target protein is approximately 43 kDa, while the observed molecular weight stands at 60 kDa.

• Related Disease
• Morphine Dependence and Cocaine Dependence

• Purification
• Affinity Purified

• Format
• Liquid

• Concentration
• Please refer to the vial label for the specific concentration.

• Storage
• Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

• Application Notes
• Western Blot: 1/500-1/1000
  Immunoprecipitation: 1/20

• Alternative Names
• Opioid Receptor Kappa 1; K-OR-1; KOR-1; OPRK; Kappa-Type Opioid Receptor; Opioid Receptor, Kappa 1; Opiate Receptor, Kappa-1; Kappa Opioid Receptor; KOR

• Gene ID
• 18387

• UniProt ID
• P33534

• Sequence Similarities
• Belongs to the G-protein coupled receptor 1 family.

• Cellular Localization
• Cell membrane

• Post Translation Modifications
• Disulfide bond
  Glycoprotein
  Lipoprotein
  Palmitate

• Function
• G-protein coupled opioid receptor that functions as a receptor for endogenous alpha-neoendorphins and dynorphins, but has low affinity for beta-endorphins. Also functions as a receptor for various synthetic opioids and for the psychoactive diterpene salvinorin A. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role in the perception of pain. Plays a role in mediating reduced physical activity upon treatment with synthetic opioids. Plays a role in the regulation of salivation in response to synthetic opioids. May play a role in arousal and regulation of autonomic and neuroendocrine functions.

Isotype Control

• MOB-208CQ
• Rabbit IgG Isotype Control Antibody

Secondary Antibody

• 2ND-054CQ
• Goat Anti-Rabbit IgG Antibody, R-PE

• 2ND-059CQ
• Goat Anti-Rabbit IgG (H&L) Antibody

• 2ND-055CQ
• Chicken Anti-Rabbit IgG (H&L) Antibody

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