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    Mouse Anti-PIK3R1 Recombinant Antibody (VS3-CJ80) (CAT#: VS3-CJ80)

    This product is a mouse antibody that recognizes PIK3R1.

    Specific Inquiry
    • Size:

    • Conjugation:

    • Endotoxin:

    • Purity:

    • Formats:

    • Isotype Switching:

    • Fc Engineering:

    • Modalities:

    Custom Production

    We specialize in custom recombinant antibody production, offering seamless execution from provided sequences to high-quality antibody deliverables, ensuring optimal yield and purity.

    Sequences:
    Isotype :
    Purity :
    Endotoxin :
    Quantity :
    Conjugation :
    Fc Engineering :
    Modalities :
    Other Requirements:
    We require custom production
    • Gene Expression
    • Datasheet
    • MSDS
    • COA
    Subcellular Location
    Figure 1 IF staining of human cell line U-251 MG
    Figure 1 IF staining of human cell line U-251 MG
    (Immunofluorescent staining of human cell line U-251 MG shows localization to cytosol.)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/1216/28_C9_2_selected.jpg
    Figure 2 IHC staining of human stomach
    Figure 2 IHC staining of human stomach
    (Immunohistochemical staining of human stomach shows strong cytoplasmic positivity in parietal cells.)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/1216/ihc_selected.jpg
    Figure 3 IHC staining of human stomach
    Figure 3 IHC staining of human stomach
    (Immunohistochemical staining of human stomach shows strong positivity in a subset of glandular cells.)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/4268/ihc_selected.jpg
    Normal Tissue
    Figure 4 Cerebral cortex
    Figure 4 Cerebral cortex
    (Endothelial cells
    Staining:

    Medium

    Intensity: Moderate
    Quantity: 75%-25%
    Location: Cytoplasmic/
    membranous
    Glial cells
    Staining:

    Medium

    Intensity: Moderate
    Quantity: 75%-25%
    Location: Cytoplasmic/
    membranous
    nuclear
    Neuronal cells
    Staining:

    High

    Intensity: Strong
    Quantity:>75%
    Location: Cytoplasmic/
    membranous
    Neuropil
    Staining:

    Medium

    Intensity: Moderate
    Quantity:>75%
    Location: Cytoplasmic/
    membranous)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/4268/19234_B_7_5.jpg
    Figure 5 Colon
    Figure 5 Colon
    (Endothelial cells
    Staining:

    Medium

    Intensity: Moderate
    Quantity:>75%
    Location: Cytoplasmic/
    membranous
    Glandular cells
    Staining:

    Medium

    Intensity: Moderate
    Quantity:>75%
    Location: Cytoplasmic/
    membranous
    Peripheral nerve/ganglion
    Staining:

    Medium

    Intensity: Moderate
    Quantity:>75%
    Location: Cytoplasmic/
    membranous)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/4268/19234_A_7_3.jpg
    Figure 6 Kidney
    Figure 6 Kidney
    (Cells in glomeruli
    Staining:

    Medium

    Intensity: Moderate
    Quantity:>75%
    Location: Cytoplasmic/
    membranous
    Cells in tubules
    Staining:

    Medium

    Intensity: Moderate
    Quantity:>75%
    Location: Cytoplasmic/
    membranous)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/4268/19234_A_9_5.jpg
    Figure 7 Testis
    Figure 7 Testis
    (Cells in seminiferous ducts
    Staining:

    Medium

    Intensity: Moderate
    Quantity:>75%
    Location: Cytoplasmic/
    membranous
    Leydig cells
    Staining:

    Medium

    Intensity: Moderate
    Quantity:>75%
    Location: Cytoplasmic/
    membranous)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/4268/19234_A_6_6.jpg
    Figure 8 Breast
    Figure 8 Breast
    (Glandular cells
    Staining:

    Medium

    Intensity: Moderate
    Quantity:>75%
    Location: Cytoplasmic/
    membranous
    Myoepithelial cells
    Staining:

    Medium

    Intensity: Moderate
    Quantity: 75%-25%
    Location: Cytoplasmic/
    membranous)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/4268/19234_B_2_4.jpg
    Figure 9 Lymph node
    Figure 9 Lymph node
    (Germinal center cells
    Staining:

    High

    Intensity: Strong
    Quantity:>75%
    Location: Cytoplasmic/
    membranous
    Non-germinal center cells
    Staining:

    High

    Intensity: Strong
    Quantity:>75%
    Location: Cytoplasmic/
    membranous)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/4268/19234_A_9_8.jpg
    RNA Expression
    Figure 10 RNA cell line category: Cell line enhanced (ASC diff)
    Figure 10 RNA cell line category: Cell line enhanced (ASC diff)
    (Cell lines ordered by descending RNA expression order.)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000145675-PIK3R1
    Figure 10 RNA cell line category: Cell line enhanced (ASC diff)
    Figure 10 RNA cell line category: Cell line enhanced (ASC diff)
    (Cell lines ordered by descending RNA expression order.)
    * Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000145675-PIK3R1

    Specifications

    • Immunogen
    • Recombinant fragment of human PIK3R1 (C-terminus)
    • Host Species
    • Mouse
    • Type
    • Mouse IgG
    • Specificity
    • Human PIK3R1
    • Species Reactivity
    • Human
    • Applications
    • WB, ELISA
    • Conjugate
    • Unconjugated

    Product Property

    • Purification
    • Protein G affinity purified
    • Purity
    • >95% as determined by SDS-PAGE
    • Format
    • Liquid
    • Concentration
    • 1 mg/mL (lot specific)
    • Buffer
    • 50% Glycerol, 1% BSA, PBS, pH7.4.
    • Preservative
    • 0.02% sodium azide
    • Storage
    • Store at 4°C for short term. Aliquot and store at -20°C for long term. Avoid repeated freeze/thaw cycles.
    • Shipping
    • Ice packs

    Applications

    • Application Notes
    • This antibody has been tested for use in ELISA (1:5000-1:20000), Western Blot (1:100-1:2000).

    Target

    • Alternative Names
    • AGM7; GRB1; IMD36; p85; p85-ALPHA
    • Sequence Similarities
    • Belongs to the PI3K p85 subunit family.
    • Cellular Localization
    • Cell-cell junction, Cis-Golgi network, Cytoplasm, Cytosol, Nucleus, Plasma membrane
    • Post Translation Modifications
    • Polyubiquitinated in T-cells by CBLB; which does not promote proteasomal degradation but impairs association with CD28 and CD3Z upon T-cell activation.
      Phosphorylated. Tyrosine phosphorylated in response to signaling by FGFR1, FGFR2, FGFR3 and FGFR4. Phosphorylated by CSF1R. Phosphorylated by ERBB4. Phosphorylated on tyrosine residues by TEK/TIE2. Dephosphorylated by PTPRJ. Phosphorylated by PIK3CA at Ser-608; phosphorylation is stimulated by insulin and PDGF. The relevance of phosphorylation by PIK3CA is however unclear (By similarity).
      Phosphorylated in response to KIT and KITLG/SCF. Phosphorylated by FGR.
    • Function
    • Binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues. Plays an important role in signaling in response to FGFR1, FGFR2, FGFR3, FGFR4, KITLG/SCF, KIT, PDGFRA and PDGFRB. Likewise, plays a role in ITGB2 signaling (PubMed:17626883, PubMed:19805105, PubMed:7518429).
      Modulates the cellular response to ER stress by promoting nuclear translocation of XBP1 isoform 2 in a ER stress- and/or insulin-dependent manner during metabolic overloading in the liver and hence plays a role in glucose tolerance improvement (PubMed:20348923).

    Recommended Products

    Isotype Control

    Secondary Antibody

    Recommended Dilution Buffer

    Product Notes

    This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

    • Increased sensitivity
    • Confirmed specificity
    • High repeatability
    • Excellent batch-to-batch consistency
    • Sustainable supply
    • Animal-free production

    See more details about Hi-Affi™ recombinant antibody benefits.

    Downloads

    Download resources about recombinant antibody development and antibody engineering to boost your research.

    See other products for "PIK3R1"

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    CAT Product Name Application Type
    MOR-2711 Hi-Affi™ Recombinant Rabbit Anti-PIK3R1 Monoclonal Antibody (DS2711AB) WB, IHC, ICC, FC, IP IgG

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