Mouse Anti-SCN3A Recombinant Antibody (clone 2506W0033)
CAT#: VS-0625-FY138
This monoclonal antibody targets Sodium Voltage-Gated Channel Alpha Subunit 3 (SCN3A), a member of the voltage-gated sodium channel family. SCN3A is widely expressed and involved in the generation and propagation of action potentials. The antibody, produced in mice and reactive with human samples, is applicable in ELISA, enabling researchers to investigate SCN3A's function in neuronal signaling and disease.
Gene Expression
Normal Tissue
Figure 1 IHC staining of human caudate
Immunohistochemical staining of human caudate shows strong cytoplasmic positivity in neurons.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/35396/ihc_selected.jpg
Normal Tissue
Figure 2 Cerebral cortex
Neuronal cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Neuropil Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/35396/73252_B_9_5.jpg
Normal Tissue
Figure 3 Cerebellum
Cells in granular layer Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous Cells in molecular layer Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous Purkinje cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/35396/73252_B_7_8.jpg
Normal Tissue
Figure 4 Colon
Glandular cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Peripheral nerve/ganglion Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/35396/73252_A_8_3.jpg
Normal Tissue
Figure 5 Liver
Cholangiocytes Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/35396/73252_A_8_4.jpg
Normal Tissue
Figure 6 Kidney
Cells in tubules Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/35396/73252_A_8_5.jpg
Normal Tissue
Figure 7 Testis
Leydig cells Staining: Low Intensity: Weak Quantity: 75%-25% Pachytene spermatocytes Staining: Low Intensity: Weak Quantity:>75% Preleptotene spermatocytes Staining: Medium Intensity: Moderate Quantity:>75% Spermatogonia cells Staining: Medium Intensity: Moderate
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/35396/73252_A_4_6.jpg
RNA Expression
Figure 8 RNA cell line category: Cell line enhanced (JURKAT, Karpas-707, MOLT-4, RPTEC TERT1, SH-SY5Y)
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000153253-SCN3A
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Specifications
- Immunogen
- Human SCN3A
- Host Species
- Mouse
- Type
- Mouse IgG
- Specificity
- The antibody specifically recognizes the peptide of the Human SCN3A.
- Species Reactivity
- Human
- Clone
- 2506W0033
- Applications
- ELISA
Product Property
- Purification
- Purified with Protein A or G affinity chromatography
- Purity
- >90% as determined by SDS-PAGE
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- The buffer commonly used is typically composed of 1 M Tris-HCl and 100 mM glycine. For more detailed information, refer to the Certificate of Analysis (COA).
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- ELISA: 1:1000-1:3000
Other applications are under development. Optimal dilutions for assays should be determined by the user.
Target
- Alternative Names
- Sodium Voltage-Gated Channel Alpha Subunit 3; Sodium Channel, Voltage-Gated, Type III, Alpha Polypeptide; Sodium Channel, Voltage Gated, Type III Alpha Subunit; Voltage-Gated Sodium Channel Subunit Alpha Nav1.3; Sodium Channel Protein Brain III Subunit Alpha; Sodium Channel Protein Type III Subunit Alpha; Voltage-Gated Sodium Channel Subtype III
- Gene ID
- 6328
- UniProt ID
- Q9NY46
- Long Name
- Sodium channel protein type 3 subunit alpha
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Downloadable Resources
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
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