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SCN3A

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For Research Use Only. Not For Clinical Use.


Voltage-gated sodium channels are transmembrane glycoprotein complexes composed of a large alpha subunit with 24 transmembrane domains and one or more regulatory beta subunits. They are responsible for the generation and propagation of action potentials in neurons and muscle. This gene encodes one member of the sodium channel alpha subunit gene family, and is found in a cluster of five alpha subunit genes on chromosome 2. Multiple transcript variants encoding different isoforms have been found for this gene.
Protein class

Disease related genes, FDA approved drug targets, Human disease related genes, Plasma proteins, Voltage-gated ion channels

Predicted location

Membrane

Single cell type specificity

Cell type enhanced (Oligodendrocyte precursor cells, Excitatory neurons, Inhibitory neurons, Early spermatids)

Immune cell specificity

Group enriched (naive B-cell, memory B-cell)

Cell line specificity

Cell line enhanced (JURKAT, Karpas-707, MOLT-4, RPTEC TERT1, SH-SY5Y)

Interaction

Heterooligomer of a large alpha subunit and 2-3 smaller beta subunits. Heterooligomer with SCN2B or SCN4B; disulfide-linked. Interacts with NEDD4L (PubMed:15548568). Interacts with the conotoxin GVIIJ (PubMed:24497506).

Molecular function

Ion channel, Sodium channel, Voltage-gated channel

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