Mouse Anti-TRIM29 Recombinant Antibody (clone 8C8G5) (CAT#: VS7-0425-WR1050)
This product is a mouse IgG2a antibody that binds to human TRIM29. The antibody 8C8G5 recognizes specific amino acid domain of human TRIM29 (AA: 451-588). It can be used for WB, ICC, and FC assays.
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We specialize in custom recombinant antibody production, offering seamless execution from provided sequences to high-quality antibody deliverables, ensuring optimal yield and purity.
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Subcellular Location
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line SiHa
(Immunofluorescent staining of human cell line SiHa shows localization to intermediate filaments.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/20053/if_selected.jpg
(Immunofluorescent staining of human cell line SiHa shows localization to intermediate filaments.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/20053/if_selected.jpg
Figure 2 Esophagus
(High expression)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/20053/46556_B_4_1_val_selected.jpg
(High expression)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/20053/46556_B_4_1_val_selected.jpg
Figure 3 IHC staining of human spleen
(Immunohistochemical staining of human spleen shows strong nuclear and cytoplasmic positivity in cells in red pulp.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/74841/169666_B_9_4_selected.jpg
(Immunohistochemical staining of human spleen shows strong nuclear and cytoplasmic positivity in cells in red pulp.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/74841/169666_B_9_4_selected.jpg
Figure 4 Cerebral cortex
(Endothelial cells Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/20053/46556_B_9_5.jpg
(Endothelial cells Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/20053/46556_B_9_5.jpg
Figure 5 Skin
(Cells in basal layer Staining: High Intensity: Strong Quantity:>75% Cells in granular layer Staining: High Intensity: Strong Quantity:>75% Cells in spinous layer Staining: High Intensity: Strong Quantity:>75% Langerhans cells Staining: High Intensity: Strong Quantity:>75%)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/20053/46556_B_8_1.jpg
(Cells in basal layer Staining: High Intensity: Strong Quantity:>75% Cells in granular layer Staining: High Intensity: Strong Quantity:>75% Cells in spinous layer Staining: High Intensity: Strong Quantity:>75% Langerhans cells Staining: High Intensity: Strong Quantity:>75%)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/20053/46556_B_8_1.jpg
Figure 6 RNA cell line category: Cell line enhanced (HaCaT, HBEC3-KT, hTCEpi, RT4, SiHa)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000137699-TRIM29
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000137699-TRIM29
Specifications
- Immunogen
- Recombinant human TRIM29 (AA: 451-588) fragment expressed in E. Coli.
- Host Species
- Mouse
- Type
- Mouse IgG2a
- Specificity
- Human TRIM29
- Species Reactivity
- Human
- Clone
- 8C8G5
- Molecule Class
- Trim Protein
- Applications
- WB, ICC, FC
- Conjugate
- Unconjugated
Product Property
- Clonality
- Monoclonal
- Purity
- >95% as determined by SDS-PAGE and SEC-HPLC analysis
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS
- Preservative
- 0.05% sodium azide
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- Western Blot: 1:500 - 1:2000
Immunocytochemistry: 1:100 - 1:500
Flow Cytometry: 1:200 - 1:400
Enzyme-linked Immunosorbent Assay: 1:10000
Target
- Alternative Names
- TRIM29; Tripartite Motif Containing 29; Tripartite Motif-Containing 29; Ataxia-Telangiectasia Group D-Associated Protein; Tripartite Motif-Containing Protein 29; ATDC; Tripartite Motif Protein TRIM29; Ataxia Telangiectasia Group D-Associated Protein
- Gene ID
- 23650
- UniProt ID
- Q14134
- Long Name
- Tripartite Motif Containing 29
- Cellular Localization
- Cytoplasm; Lysosome
- Post Translation Modifications
- Phosphoprotein
- Protein Refseq
- NP_001317311.1
- Function
- Plays a crucial role in the regulation of macrophage activation in response to viral or bacterial infections within the respiratory tract. Mechanistically, TRIM29 interacts with IKBKG/NEMO in the lysosome where it induces its 'Lys-48' ubiquitination and subsequent degradation. In turn, the expression of type I interferons and the production of pro-inflammatory cytokines are inhibited. Additionally, induces the 'Lys-48' ubiquitination of STING1 in a similar way, leading to its degradation.
Recommended Products
Isotype Control
Secondary Antibody
Reconstitution Buffer
Recommended Dilution Buffer
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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IHC Kit and Antibody Products: Precision Tools for Immunohistochemistry
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-3462z | Mouse Anti-TRIM29 Recombinant Antibody (clone 22D5) | WB, IP, IF, ELISA | Mouse IgG1, κ |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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