Rabbit Anti-UHRF1 Recombinant Antibody (VS13-YC1204)
CAT#: VS13-YC1204
The Rabbit Anti-UHRF1 Recombinant Antibody is specific for human UHRF1. UHRF1 is an E3 ubiquitin ligase regulating gene expression and cell cycle transition. It's upregulated in cancers and is a potential therapeutic target. The anti-UHRF1 antibody can be used for Immunohistochemistry (1/100-1/200).
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line MCF7
Immunofluorescent staining of human cell line MCF7 shows localization to nucleoplasm.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/49408/if_selected.jpg
Normal Tissue
Figure 2 Colon
Enterocytes -
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/55446/165825_A_8_3.jpg
Normal Tissue
Figure 3 Testis
Cells in seminiferous ducts Staining: Low Intensity: Moderate Quantity: <25% Location: Nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/55446/165825_A_6_6.jpg
Normal Tissue
Figure 4 Lymph node
Non-germinal center cells Staining: Medium Intensity: Strong Quantity: <25% Location: Nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/55446/165825_A_7_8.jpg
RNA Expression
Figure 5 RNA cell line category: Cell line enhanced (MOLT-4, REH)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000276043-UHRF1
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Specifications
- Immunogen
- Recombinant human UHRF1.
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human UHRF1
- Species Reactivity
- Human
- Applications
- IHC-P
- Conjugate
- NONE
Product Property
- Clonality
- Monoclonal
- Purification
- Affinity Chromatography purified
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS (pH 7.2) containing 50% Glycerol and 0.5% BSA.
- Preservative
- 0.02% Sodium azide
- Storage
- Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Shipping with ice pack.
Applications
- Application Notes
- Immunohistochemistry (IHC): 1/100-1/200
Target
- Alternative Names
- Ubiquitin Like With PHD And Ring Finger Domains 1; Ubiquitin-Like PHD And RING Finger Domain-Containing Protein 1; Inverted CCAAT Box-Binding Protein Of 90 KDa; RING-Type E3 Ubiquitin Transferase UHRF1; Nuclear Zinc Finger Protein Np95; Transcription Factor ICBP90; RING Finger Protein 106; Nuclear Protein 95; HuNp95; ICBP90; RNF106;
- Gene ID
- 29128
- UniProt ID
- Q96T88
- Long Name
- Ubiquitin Like With PHD And Ring Finger Domains 1
- Cellular Localization
- Nucleus
- Protein Refseq
- NP_001041666.1; NP_001276979.1; NP_001276980.1
- Function
- Multidomain protein that acts as a key epigenetic regulator by bridging DNA methylation and chromatin modification. Specifically recognizes and binds hemimethylated DNA at replication forks via its YDG domain and recruits DNMT1 methyltransferase to ensure faithful propagation of the DNA methylation patterns through DNA replication. In addition to its role in maintenance of DNA methylation, also plays a key role in chromatin modification: through its tudor-like regions and PHD-type zinc fingers, specifically recognizes and binds histone H3 trimethylated at 'Lys-9' (H3K9me3) and unmethylated at 'Arg-2' (H3R2me0), respectively, and recruits chromatin proteins. Enriched in pericentric heterochromatin where it recruits different chromatin modifiers required for this chromatin replication. Also localizes to euchromatic regions where it negatively regulates transcription possibly by impacting DNA methylation and histone modifications. Has E3 ubiquitin-protein ligase activity by mediating the ubiquitination of target proteins such as histone H3 and PML. It is still unclear how E3 ubiquitin-protein ligase activity is related to its role in chromatin in vivo. Plays a role in DNA repair by cooperating with UHRF1 to ensure recruitment of FANCD2 to interstrand cross-links (ICLs) leading to FANCD2 activation.
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Secondary Antibody
- CAT
- Product Name
Isotype Control
- CAT
- Product Name
See other products for "UHRF1"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| ZG-0495F | Mouse Anti-UHRF1 Recombinant Antibody (ZG-0495F) | WB, IF | Mouse IgG |
| ZG-0496F | Mouse Anti-UHRF1 Recombinant Antibody (ZG-0496F) | WB | Mouse IgG |
| VS7-0425-WR1087 | Mouse Anti-UHRF1 Recombinant Antibody (clone 2A8C7) | WB, IHC | Mouse IgG1 |
| VS7-0425-WR1088 | Mouse Anti-UHRF1 Recombinant Antibody (clone 1A1B1) | WB, IHC, ICC, FC | Mouse IgG2b |
| VS7-0425-WR1089 | Mouse Anti-UHRF1 Recombinant Antibody (VS7-0425-WR1089) | WB, IF, ICC | Mouse IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-XY2434 | Anti-UHRF1 Immunohistochemistry Kit | IHC | |
| VS-0525-XY7739 | Anti-Mouse UHRF1 Immunohistochemistry Kit | IHC | |
| VS-0525-XY7738 | Anti-Human UHRF1 Immunohistochemistry Kit | IHC | |
| VS-0525-XY7740 | Anti-Rat UHRF1 Immunohistochemistry Kit | IHC |
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