APC-HLA-A*24:02/SARS-CoV-2 S (YFPLQSYGF) MHC Tetramer (CAT#: MHC-YF3476)
This product is a MHC tetramer of biotinylated peptide/MHC complex composed S-derived peptide of YFPLQSYGF sequence covering 489-497 and HLA-A*24:02 molecule. The pMHC tetramer recognizes CD8 T cells and can be used in the MHC tetramer analysis of individual antigen-specific T cells.
Specific Inquiry
Specifications
- Allele
- HLA-A*24:02
- Class
- Class I
- Antigen
- S
- Antigen Species
- SARS-CoV-2
- Peptide
- YFPLQSYGF
- Range
- 489-497
- Conjugate
- APC
- Application
- FCM
Target
- Antigen Introduction
- The spike (S) glycoprotein of coronaviruses contains protrusions that will only bind to certain receptors on the host cell. The spike (S) glycoprotein of coronaviruses is known to be essential in the binding of the virus to the host cell at the advent of the infection process. It's been reported that 2019-nCoV can infect the human respiratory epithelial cells through interaction with the human ACE2 receptor. The spike protein is a large type I transmembrane protein containing two subunits, S1 and S2. S1 mainly contains a receptor binding domain (RBD), which is responsible for recognizing the cell surface receptor. S2 contains basic elements needed for the membrane fusion.The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity. The main functions for the Spike protein are summarized as: Mediate receptor binding and membrane fusion; Defines the range of the hosts and specificity of the virus; Main component to bind with the neutralizing antibody; Key target for vaccine design; Can be transmitted between different hosts through gene recombination or mutation of the receptor binding domain (RBD), leading to a higher mortality rate.
- Alternative Names
- S, S glycoprotein, Spike, Spike glycoprotein, E2 glycoprotein precursor, SARS-CoV-2, SARS-CoV-2 S, SARS-CoV-2 Spike, 2019-nCoV, 2019-nCoV S, 2019-nCoV Spike
- Gene ID
- 43740568
Downloads
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Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PABC-055 | Recombinant Mouse Anti-HBV PS1 peptide (HQLDPAFGANSTNPD) Antibody (PC282 ) | Neut | IgG |
| PABZ-055 | Recombinant Mouse Anti-HBV PS1 peptide (HQLDPAFGANSTNPD) Antibody (PC283) | Neut | IgG |
| PABW-055 | Recombinant Mouse Anti-HBV PS1 peptide (HQLDPAFGANSTNPD) Antibody (PC287) | Neut | IgG |
| PABC-115 | Recombinant Human Anti-SCV S RBD Antibody (80R) | Neut | IgG |
Fab Fragment Antibody
scFv Fragment Antibody
MHC Tetramer for Virology
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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