DRB1*04:01/Human cit CILP (ATIKAEFV[cit]AETPYM) MHC Monomer (CAT#: MHC-YF040)
This product is a MHC monomer of biotinylated peptide/MHC complex composed cit CILP-derived peptide of ATIKAEFV[cit]AETPYM sequence covering 297–311 and DRB1*04:01 molecule. The pMHC monomer recognizes human CD8 T cells and can be used in the MHC tetramer analysis of individual antigen-specific T cells.
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Custom Production
MHC tetramer custom production provides a vital tool for researchers seeking to understand and manipulate T-cell immunity with exceptional precision. Please specify your requirements, including peptide sequence, MHC allele, and desired fluorophore etc. We will respond as soon as possible with a tailored solution.
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Normal Tissue
RNA Expression
Figure 1 IHC staining of human ovary
(Immunohistochemical staining of human ovary shows strong cytoplasmic positivity in follicle cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/3195/ihc_selected.jpg
(Immunohistochemical staining of human ovary shows strong cytoplasmic positivity in follicle cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/3195/ihc_selected.jpg
Figure 2 Cerebral cortex
(Neuronal cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous Neuropil Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/3195/9797_B_8_5.jpg
(Neuronal cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous Neuropil Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/3195/9797_B_8_5.jpg
Figure 3 Liver
(Cholangiocytes Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous Hepatocytes Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/3195/9797_A_7_4.jpg
(Cholangiocytes Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous Hepatocytes Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/3195/9797_A_7_4.jpg
Figure 4 Kidney
(Cells in glomeruli Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/3195/9797_A_9_5.jpg
(Cells in glomeruli Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/3195/9797_A_9_5.jpg
Figure 5 Testis
(Leydig cells Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/3195/9797_A_4_6.jpg
(Leydig cells Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/3195/9797_A_4_6.jpg
Figure 6 RNA cell line category: Cell line enhanced (ASC diff, ASC TERT1, EFO-21, HSkMC)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000138615-CILP
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000138615-CILP
Specifications
- Allele
- DRB1*04:01
- Class
- Class II
- MHC Species
- Human
- Antigen
- cit CILP
- Antigen Species
- Human
- Peptide
- ATIKAEFV[cit]AETPYM
- Range
- 297–311
- Conjugate
- Biotin
- Application
- MHC Multimer
Target
- Antigen Introduction
- Major alterations in the composition of the cartilage extracellular matrix occur in joint disease, such as osteoarthrosis. This gene encodes the cartilage intermediate layer protein (CILP), which increases in early osteoarthrosis cartilage. The encoded protein was thought to encode a protein precursor for two different proteins; an N-terminal CILP and a C-terminal homolog of NTPPHase, however, later studies identified no nucleotide pyrophosphatase phosphodiesterase (NPP) activity. The full-length and the N-terminal domain of this protein was shown to function as an IGF-1 antagonist. An allelic variant of this gene has been associated with lumbar disc disease.
- Alternative Names
- CILP-1; HsT18872
- Gene ID
- 8483
- UniProt ID
- O75339
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IgG Antibody Products
MHC Tetramer Products for Other Applications
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1896z | Mouse Anti-CILP Recombinant Antibody (clone 29D11) | WB, ELISA, IF, IP | Mouse IgG1, κ |
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