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CILP

Anti-CILP Products

Mouse Anti-CILP Recombinant Antibody (clone 29D11) (MOB-1896z)
- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1, κ
- Application: WB, ELISA, IF, IP
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DRB1*04:01/Human cit CILP (ATIKAEFV[cit]AETPYM) MHC Monomer (MHC-YF040)
- Class: Class II
- Antigen: cit CILP
- Antigen Species: Human
- Peptide: ATIKAEFV[cit]AETPYM
- Conjugate: Biotin
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DRB1*04:01/Human cit CILP (GKLYGI[cit]DV[cit]STRDR) MHC Monomer (MHC-YF041)
- Class: Class II
- Antigen: cit CILP
- Antigen Species: Human
- Peptide: GKLYGI[cit]DV[cit]STRDR
- Conjugate: Biotin
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For Research Use Only. Not For Clinical Use.

Probably plays a role in cartilage scaffolding. May act by antagonizing TGF-beta1 (TGFB1) and IGF1 functions. Has the ability to suppress IGF1-induced proliferation and sulfated proteoglycan synthesis, and inhibits ligand-induced IGF1R autophosphorylation. May inhibit TGFB1-mediated induction of cartilage matrix genes via its interaction with TGFB1. Overexpression may lead to impair chondrocyte growth and matrix repair and indirectly promote inorganic pyrophosphate (PPi) supersaturation in aging and osteoarthritis cartilage.

Protein class

Disease related genes

Predicted location

Secreted

Single cell type specificity

Cell type enhanced (Leydig cells, Fibroblasts, Theca cells, Peritubular cells, Endometrial stromal cells)

Immune cell specificity

Not detected in immune cells

Cell line specificity

Cell line enhanced (ASC diff, ASC TERT1, EFO-21, HSkMC)

Interaction

Monomer. Interacts with TGFB1.

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