DRB1*04:01/Human cit CILP (GKLYGI[cit]DV[cit]STRDR) MHC Monomer
CAT#: MHC-YF041
This product is a MHC monomer of biotinylated peptide/MHC complex composed cit CILP-derived peptide of GKLYGI[cit]DV[cit]STRDR sequence covering 982–996 and DRB1*04:01 molecule. The pMHC monomer recognizes human CD8 T cells and can be used in the MHC tetramer analysis of individual antigen-specific T cells.
Gene Expression
Normal Tissue
Figure 1 IHC staining of human ovary
Immunohistochemical staining of human ovary shows strong cytoplasmic positivity in follicle cells.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/3195/ihc_selected.jpg
Normal Tissue
Figure 2 Cerebral cortex
Neuronal cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous Neuropil Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/3195/9797_B_8_5.jpg
Normal Tissue
Figure 3 Liver
Cholangiocytes Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous Hepatocytes Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/3195/9797_A_7_4.jpg
Normal Tissue
Figure 4 Kidney
Cells in glomeruli Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/3195/9797_A_9_5.jpg
Normal Tissue
Figure 5 Testis
Leydig cells Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/3195/9797_A_4_6.jpg
RNA Expression
Figure 6 RNA cell line category: Cell line enhanced (ASC diff, ASC TERT1, EFO-21, HSkMC)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000138615-CILP
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Specifications
- Allele
- DRB1*04:01
- Class
- Class II
- MHC Species
- Human
- Antigen
- cit CILP
- Antigen Species
- Human
- Peptide
- GKLYGI[cit]DV[cit]STRDR
- Range
- 982–996
- Conjugate
- Biotin
- Application
- MHC Multimer
Target
- Antigen Introduction
- Major alterations in the composition of the cartilage extracellular matrix occur in joint disease, such as osteoarthrosis. This gene encodes the cartilage intermediate layer protein (CILP), which increases in early osteoarthrosis cartilage. The encoded protein was thought to encode a protein precursor for two different proteins; an N-terminal CILP and a C-terminal homolog of NTPPHase, however, later studies identified no nucleotide pyrophosphatase phosphodiesterase (NPP) activity. The full-length and the N-terminal domain of this protein was shown to function as an IGF-1 antagonist. An allelic variant of this gene has been associated with lumbar disc disease.
- Alternative Names
- CILP-1; HsT18872
- Gene ID
- 8483
- UniProt ID
- O75339
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Datasheet
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COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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See other products for "CILP"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1896z | Mouse Anti-CILP Recombinant Antibody (clone 29D11) | WB, ELISA, IF, IP | Mouse IgG1, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-YF040 | DRB1*04:01/Human cit CILP (ATIKAEFV[cit]AETPYM) MHC Monomer | MHC Multimer |
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