Human Anti-PA scFv-Fc Chimera (VS-0425-FY67) (CAT#: VS-0425-FY67)
This scFv-Fc fusion targets PA (Protective antigen of anthrax toxin) and is being researched for its potential use in anthrax vaccine development or toxin neutralization, offering a targeted approach to counteract the effects of anthrax toxin.
Specific Inquiry
Custom Production
We specialize in custom recombinant antibody production, offering seamless execution from provided sequences to high-quality antibody deliverables, ensuring optimal yield and purity.
We require custom production
Specifications
- Host Species
- Human
- Type
- Human IgG1, scFv-Fc
- Specificity
- Bacillus anthracis anthrax protective antigen
- Species Reactivity
- B. anthracis
- Applications
- Western Blot, ELISA
- Related Disease
- B. anthracis
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- The optimal dilution concentration is determined by the experiment.
Target
- Alternative Names
- Anthrax protective antigen; PA
- Long Name
- Anthrax protective antigen
- Function
- The gene for the protective antigen (PA) of anthrax toxin is pagA. However, "protective antigen" typically refers to the protein itself, not just the gene.
The Protective Antigen (PA) is a crucial component of the anthrax toxin produced by Bacillus anthracis. Its primary function is to facilitate the entry of the toxin's enzymatic components, Lethal Factor (LF) and Edema Factor (EF), into host cells. PA first binds to cell surface receptors and is then cleaved by a host protease. The resulting fragment oligomerizes to form a heptameric or octameric ring structure on the cell surface. This ring then binds LF and/or EF. The entire complex is internalized by endocytosis. Within the acidic environment of the endosome, PA undergoes a conformational change to form a transmembrane pore, allowing LF and EF to translocate into the host cell cytosol, where they exert their toxic effects. Without PA, LF and EF cannot enter cells and are non-toxic.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| PABC-099 | Mouse Anti-PA Recombinant Antibody (clone 14B7*) | Neut | Mouse IgG |
| PABZ-099 | Mouse Anti-PA Recombinant Antibody (clone 1H) | Neut | Mouse IgG |
| PABW-099 | Mouse Anti-PA Recombinant Antibody (clone M18) | Neut | Mouse IgG |
| HPAB-J0202-YC | Mouse Anti-PA Recombinant Antibody (HPAB-J0202-YC) | ELISA, Neut | Mouse IgG |
| HPAB-J0203-YC | Mouse Anti-PA Recombinant Antibody (HPAB-J0203-YC) | ELISA, Neut | Mouse IgG |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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