Human Anti-PA scFv-Fc Chimera (VS-0425-FY67)
CAT#: VS-0425-FY67
This scFv-Fc fusion targets PA (Protective antigen of anthrax toxin) and is being researched for its potential use in anthrax vaccine development or toxin neutralization, offering a targeted approach to counteract the effects of anthrax toxin.
Specifications
- Host Species
- Human
- Type
- Human IgG1, scFv-Fc
- Specificity
- Bacillus anthracis anthrax protective antigen
- Species Reactivity
- B. anthracis
- Applications
- Western Blot, ELISA
- Related Disease
- B. anthracis
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- The optimal dilution concentration is determined by the experiment.
Target
- Alternative Names
- Anthrax protective antigen; PA
- Long Name
- Anthrax protective antigen
- Function
- The gene for the protective antigen (PA) of anthrax toxin is pagA. However, "protective antigen" typically refers to the protein itself, not just the gene.
The Protective Antigen (PA) is a crucial component of the anthrax toxin produced by Bacillus anthracis. Its primary function is to facilitate the entry of the toxin's enzymatic components, Lethal Factor (LF) and Edema Factor (EF), into host cells. PA first binds to cell surface receptors and is then cleaved by a host protease. The resulting fragment oligomerizes to form a heptameric or octameric ring structure on the cell surface. This ring then binds LF and/or EF. The entire complex is internalized by endocytosis. Within the acidic environment of the endosome, PA undergoes a conformational change to form a transmembrane pore, allowing LF and EF to translocate into the host cell cytosol, where they exert their toxic effects. Without PA, LF and EF cannot enter cells and are non-toxic.
REVIEWS AND Q&AS
CITATIONS
RESOURCES
DOWNLOADS
RELATED PRODUCTS
Inquiry
Navs
Customer Review
There are currently no Customer reviews or questions for VS-0425-FY67. Click the button above to contact us or submit your feedback about this product.
Submit Your Publication
Published with our product? Submit your paper and receive a 10% discount on your next order! Share your research to earn exclusive rewards.
Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
See other products for "PA"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PABC-099 | Mouse Anti-PA Recombinant Antibody (clone 14B7*) | Neut | Mouse IgG |
| PABZ-099 | Mouse Anti-PA Recombinant Antibody (clone 1H) | Neut | Mouse IgG |
| PABW-099 | Mouse Anti-PA Recombinant Antibody (clone M18) | Neut | Mouse IgG |
| HPAB-J0202-YC | Mouse Anti-PA Recombinant Antibody (HPAB-J0202-YC) | ELISA, Neut | Mouse IgG |
| HPAB-J0203-YC | Mouse Anti-PA Recombinant Antibody (HPAB-J0203-YC) | ELISA, Neut | Mouse IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PFBC-099 | Mouse Anti-PA Recombinant Antibody (clone 14B7*); Fab Fragment | Neut | Mouse Fab |
| PFBZ-099 | Mouse Anti-PA Recombinant Antibody (clone 1H); Fab Fragment | Neut | Mouse IgG |
| PFBW-099 | Mouse Anti-PA Recombinant Antibody (clone M18); Fab Fragment | Neut | Mouse Fab |
| HPAB-J0202-YC-F(E) | Mouse Anti-PA Recombinant Antibody; Fab Fragment (HPAB-J0202-YC-F(E)) | ELISA, Neut | Mouse Fab |
| HPAB-J0203-YC-F(E) | Mouse Anti-PA Recombinant Antibody; Fab Fragment (HPAB-J0203-YC-F(E)) | ELISA, Neut | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PSBC-099 | Mouse Anti-PA Recombinant Antibody (clone 14B7*); scFv Fragment | Neut | Mouse scFv |
| PSBZ-099 | Mouse Anti-PA Recombinant Antibody (clone 1H); scFv Fragment | Neut | Mouse scFv |
| PSBW-099 | Mouse Anti-PA Recombinant Antibody (clone M18); scFv Fragment | Neut | Mouse scFv |
| HPAB-J0202-YC-S(P) | Mouse Anti-PA Recombinant Antibody; scFv Fragment (HPAB-J0202-YC-S(P)) | ELISA, Neut | Mouse scFv |
| HPAB-J0203-YC-S(P) | Mouse Anti-PA Recombinant Antibody; scFv Fragment (HPAB-J0203-YC-S(P)) | ELISA, Neut | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MRO-059CT-S(P) | Anti-B. anthracis protective antigen Recombinant Antibody scFv Fragment (MRO-059CT-S(P)) | ELISA, WB | Human antibody |
| MRO-060CT-S(P) | Anti-B. anthracis protective antigen Recombinant Antibody scFv Fragment (MRO-060CT-S(P)) | ELISA, WB | Human antibody |
| MRO-061CT-S(P) | Anti-B. anthracis protective antigen Recombinant Antibody scFv Fragment (MRO-061CT-S(P)) | ELISA, WB | Human antibody |
| MRO-062CT-S(P) | Anti-B. anthracis protective antigen Recombinant Antibody scFv Fragment (MRO-062CT-S(P)) | ELISA, WB | Human antibody |
| MRO-063CT-S(P) | Anti-B. anthracis protective antigen Recombinant Antibody scFv Fragment (2A6) | ELISA, Neut | Human antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-440CQ | Anti-Bacillus Anthracis PA Recombinant Antibody (TAB-440CQ) | ELISA, IHC, FC, IP, IF, FuncS | IgG1, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-YF670 | H-2Db/Influenza A Polymerase acidic protein (SSLENFRAYV) MHC Pentamer | FCM | |
| MHC-YF671 | H-2Db/Influenza A Polymerease PA (SCLENFRAYV) MHC Pentamer | FCM |
Specific Inquiry
Add to compare
See Our Custom Production in Action
Popular Products
Application: FC, IP, ELISA, Neut, FuncS, IF, IHC
Application: WB, IF, IP, Neut, FuncS, ELISA, FC
Application: WB, FC, IP, ELISA, Neut, FuncS, IF
Application: IP, IF, FuncS, FC, Neut, ELISA, IHC
Application: ELISA, IP, FC, FuncS, Neut, IF, ICC
Application: WB, Neut, FuncS
Application: ELISA, SPR, Inhib, FuncS
Application: ELISA, IHC, FC, IP, IF, FuncS
Application: ELISA, Neut
Application: ELISA, Inhib, FuncS
Application: ELISA, FC, Inhib, IHC-Fr, WB, IP
Application: EM, ELISA, ICC, IHC-Fr, IHC-P, WB
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
Send Inquiry
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
