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    Recombinant Human Anti-SCN3A Soluble TCR (NA4) (C-Cys) (CAT#: VS-0622-YF5048)

    Human TCR (NA4) recognizes SCN3A peptide (ALVGAIPSI) in the context of HLA-A2. Soluble TCR is expressed with C-terminal Cys strategy (TRAV-TRAC partial-Cys, TRBV-TRBC partial-Cys). Depending the C-terminal Cys, two chains form heterodimer. Please note that the activity is not guaranteed.

    Specific Inquiry
    • Size:

    • Conjugation:

    • Gene Expression
    • Datasheet
    • MSDS
    • COA
    Normal Tissue
    Figure 1 IHC staining of human caudate
    Figure 1 IHC staining of human caudate
    (Immunohistochemical staining of human caudate shows strong cytoplasmic positivity in neurons.)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/35396/ihc_selected.jpg
    Figure 2 Cerebral cortex
    Figure 2 Cerebral cortex
    (Neuronal cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Neuropil Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/35396/73252_B_9_5.jpg
    Figure 3 Cerebellum
    Figure 3 Cerebellum
    (Cells in granular layer Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous Cells in molecular layer Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous Purkinje cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/35396/73252_B_7_8.jpg
    Figure 4 Colon
    Figure 4 Colon
    (Glandular cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Peripheral nerve/ganglion Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/35396/73252_A_8_3.jpg
    Figure 5 Liver
    Figure 5 Liver
    (Cholangiocytes Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/35396/73252_A_8_4.jpg
    Figure 6 Kidney
    Figure 6 Kidney
    (Cells in tubules Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/35396/73252_A_8_5.jpg
    Figure 7 Testis
    Figure 7 Testis
    (Leydig cells Staining: Low Intensity: Weak Quantity: 75%-25% Pachytene spermatocytes Staining: Low Intensity: Weak Quantity:>75% Preleptotene spermatocytes Staining: Medium Intensity: Moderate Quantity:>75% Spermatogonia cells Staining: Medium Intensity: Moderate)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/35396/73252_A_4_6.jpg
    RNA Expression
    Figure 8 RNA cell line category: Cell line enhanced (JURKAT, Karpas-707, MOLT-4, RPTEC TERT1, SH-SY5Y)
    Figure 8 RNA cell line category: Cell line enhanced (JURKAT, Karpas-707, MOLT-4, RPTEC TERT1, SH-SY5Y)
    (Cell lines ordered by descending RNA expression order)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000153253-SCN3A

    Specifications

    • Host Species
    • Human
    • Target
    • SCN3A
    • Species Reactivity
    • Human
    • Epitope
    • ALVGAIPSI
    • MHC
    • HLA-A2
    • Clone
    • NA4
    • Type
    • Soluble TCR (C-Cys)
    • TCR Expression Strategy
    • C-Cys strategy: the alpha and beta chain (without transmembrane and cytosolic region) can form heterodimer based on C-terminal Cys. The soluble TCR contains variable regions and partial constant regions.

    Target

    • Alternative Names
    • Sodium Voltage-Gated Channel Alpha Subunit 3; Sodium Channel, Voltage-Gated, Type III, Alpha Polypeptide; Sodium Channel, Voltage Gated, Type III Alpha Subunit; Voltage-Gated Sodium Channel Subunit Alpha Nav1.3; Sodium Channel Protein Brain III Subunit Alpha; Sodium Channel Protein Type III Subunit Alpha; Voltage-Gated Sodium Channel Subtype III

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