Human Anti-Tn (clone 83D4) scFv-Fc Chimera (CAT#: VS-0125-FY78)
The Anti-Tn scFv-Fc represents a novel approach to developing targeted cancer immunotherapy against the Tn antigen, which is a tumor-associated carbohydrate marker. The unique structure of the Tn antigen, specifically the GalNAc(α1-3)-Ser/Thr modification, poses challenges in generating effective antibodies through traditional hybridoma techniques due to its small size and simple conformation. These findings highlight the promise of phage display technology in generating specific antibodies that can be further developed into Fc-fusion proteins for therapeutic use. The implications of this approach extend to creating innovative treatments for cancers characterized by high expression of the Tn antigen, potentially leading to improved patient outcomes in cancer immunotherapy.
Specific Inquiry
Specifications
- Host Species
- Human
- Type
- Human IgG1, scFv-Fc
- Species Reactivity
- Human
- Clone
- 83D4
- Applications
- ELISA, Antibody-dependent cellular cytotoxicity
- Related Disease
- Cancer
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS
- Preservative
- No preservatives
- Stabilizer
- No Stabilizers
- Sterility
- 0.2 μM filtered
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Target
- Alternative Names
- Tn antigen, Tn
Recommended Products
Secondary Antibody
Isotype Control
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
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IgG Antibody Products
ScFv Antibody Products
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ScFv-Fc Chimera Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-1432-FY | Mouse Anti-TN Recombinant Antibody (HPAB-1432-FY) | IHC, FC | Mouse IgG |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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