Human Anti-Tn (clone 83D4) scFv-Fc Chimera
CAT#: VS-0125-FY78
The Anti-Tn scFv-Fc represents a novel approach to developing targeted cancer immunotherapy against the Tn antigen, which is a tumor-associated carbohydrate marker. The unique structure of the Tn antigen, specifically the GalNAc(α1-3)-Ser/Thr modification, poses challenges in generating effective antibodies through traditional hybridoma techniques due to its small size and simple conformation. These findings highlight the promise of phage display technology in generating specific antibodies that can be further developed into Fc-fusion proteins for therapeutic use. The implications of this approach extend to creating innovative treatments for cancers characterized by high expression of the Tn antigen, potentially leading to improved patient outcomes in cancer immunotherapy.
Specifications
- Host Species
- Human
- Type
- Human IgG1, scFv-Fc
- Species Reactivity
- Human
- Clone
- 83D4
- Applications
- ELISA, Antibody-dependent cellular cytotoxicity
- Related Disease
- Cancer
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS
- Preservative
- No preservatives
- Stabilizer
- No Stabilizers
- Sterility
- 0.2 μM filtered
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Target
- Alternative Names
- Tn antigen, Tn
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Downloadable Resources
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Secondary Antibody
- CAT
- Product Name
Isotype Control
- CAT
- Product Name
See other products for "TN"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-1432-FY | Mouse Anti-TN Recombinant Antibody (HPAB-1432-FY) | IHC, FC | Mouse IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-1432-FY-F(E) | Mouse Anti-TN Recombinant Antibody; Fab Fragment (HPAB-1432-FY-F(E)) | IHC, FC | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-1432-FY-S(P) | Mouse Anti-TN Recombinant Antibody; scFv Fragment (HPAB-1432-FY-S(P)) | IHC, FC | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0125-FY100 | Mouse Anti-Tn scFv-Fc Chimera (VS-0125-FY100) | ELISA, WB | Human IgG1, scFv-Fc |
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