Protein A C domain scaffolds

Protein A ScaffoldsProtein A C domain scaffold molecules, a class of antibody mimetics, are engineered single domain proteins for therapeutic, diagnostic and biotechnological applications. An Protein A C domain scaffold molecules consists of three alpha helices with 58 amino acids, with molecular weight only around 6 kDa, are derived from one of the IgG-binding domains of staphylococcal protein A.

Advantages of Protein A C domain scaffolds:
• Enable bi-specific binding
• Extended half life
• Site-specificity
• Excellent tissue penetration

Creative Biolabs has created a large library consisting of more than ten billion Protein A C domain scaffold molecules, all with unique binding sites. Should you need further information, please feel free to contact us at

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