ADC

• Anti-EGFR-doxorubicin ADC (ADC-168LZY)
• • Target: EGFR
  • Linker: polyethylene glycol linker
  • Drug: doxorubicin
  Compare

• Anti-EDNBR (clone 5E9)-vc-MMAE ADC (ADC-169LZY)
• • Target: EDNBR
  • Linker: VC (valine-citrulline)
  • Drug: MMAE (monomethyl auristatin E)
  Compare

• Anti-FR-S-S-Dox ADC (ADC-170LZY)
• • Target: folate receptor (FR)
  • Linker: disulfide ("S-S") linker
  • Drug: doxorubicin
  Compare

• Anti-Ley (clone BR96)-mc-vc-PABC-MMAF ADC (ADC-172LZY)
• • Target: Ley
  • Linker: mc-VC-PABC (maleimidocaproyl valine-citrulline-p-aminobenzyl carbamoyl)
  • Drug: MMAF (monomethyl auristatin F)
  Compare

• Anti-Her2-SPP-DM1 ADC (ADC-173LZY)
• • Target: Her2
  • Linker: SPP (N-succinimidyl-4-(2-pyridyldithio)pentanoate)
  • Drug: DM1(N2'-deacetyl-N2'-(3-mercapto-1-oxopropyl)-maytansine)
  Compare

• Anti-Her2-MCC-DM1 ADC (ADC-174LZY)
• • Target: Her2
  • Linker: MCC (Maleimidomethyl cyclohexane-1-carboxylate)
  • Drug: DM1(N2'-deacetyl-N2'-(3-mercapto-1-oxopropyl)-maytansine)
  Compare

• Anti-Her2-mc-vc-PABC-MMAE ADC (ADC-175LZY)
• • Target: Her2
  • Linker: mc-VC-PABC (maleimidocaproyl valine-citrulline-p-aminobenzyl carbamoyl)
  • Drug: MMAE (monomethyl auristatin E)
  Compare

• Anti-Her2-mc-MMAF ADC (ADC-176LZY)
• • Target: Her2
  • Linker: mc (maleimidocaproyl)
  • Drug: MMAF (monomethyl auristatin F)
  Compare

• Anti-CD72 (clone 10D6.8.1)-SPP-DM1 ADC (ADC-177LZY)
• • Target: CD72
  • Linker: SPP (N-succinimidyl-4-(2-pyridyldithio)pentanoate)
  • Drug: DM1(N2'-deacetyl-N2'-(3-mercapto-1-oxopropyl)-maytansine)
  Compare

• Anti-CD72 (clone 10D6.8.1)-MCC-DM1 ADC (ADC-178LZY)
• • Target: CD72
  • Linker: MCC (Maleimidomethyl cyclohexane-1-carboxylate)
  • Drug: DM1(N2'-deacetyl-N2'-(3-mercapto-1-oxopropyl)-maytansine)
  Compare

• Anti-CD72 (clone 10D6.8.1)-mc-vc-PABC-MMAE ADC (ADC-179LZY)
• • Target: CD72
  • Linker: mc-VC-PABC (maleimidocaproyl valine-citrulline-p-aminobenzyl carbamoyl)
  • Drug: MMAE (monomethyl auristatin E)
  Compare

• Anti-CD72 (clone 10D6.8.1)-mc-MMAF ADC (ADC-180LZY)
• • Target: CD72
  • Linker: mc (maleimidocaproyl)
  • Drug: MMAF (monomethyl auristatin F)
  Compare

• Anti-CD19 (clone B496)-SPP-DM1 ADC (ADC-181LZY)
• • Target: CD19
  • Linker: SPP (N-succinimidyl-4-(2-pyridyldithio)pentanoate)
  • Drug: DM1(N2'-deacetyl-N2'-(3-mercapto-1-oxopropyl)-maytansine)
  Compare

• Anti-CD19 (clone B496)-MCC-DM1 ADC (ADC-182LZY)
• • Target: CD19
  • Linker: MCC (Maleimidomethyl cyclohexane-1-carboxylate)
  • Drug: DM1 (N2'-deacetyl-N2'-(3-mercapto-1-oxopropyl)-maytansine)
  Compare

• Anti-CD19 (clone B496)-mc-vc-PABC-MMAE ADC (ADC-183LZY)
• • Target: CD19
  • Linker: mc-VC-PABC (maleimidocaproyl valine-citrulline-p-aminobenzyl carbamoyl)
  • Drug: MMAE (monomethyl auristatin E)
  Compare

• Anti-CD19 (clone B496)-mc-MMAF ADC (ADC-184LZY)
• • Target: CD19
  • Linker: mc (maleimidocaproyl)
  • Drug: MMAF (monomethyl auristatin F)
  Compare

• Anti-CD20-SPP-DM1 ADC (ADC-185LZY)
• • Target: CD20
  • Linker: SPP (N-succinimidyl-4-(2-pyridyldithio)pentanoate)
  • Drug: DM1(N2'-deacetyl-N2'-(3-mercapto-1-oxopropyl)-maytansine)
  Compare

• Anti-CD20-MCC-DM1 ADC (ADC-186LZY)
• • Target: CD20
  • Linker: MCC (Maleimidomethyl cyclohexane-1-carboxylate)
  • Drug: DM1(N2'-deacetyl-N2'-(3-mercapto-1-oxopropyl)-maytansine)
  Compare

• Anti-CD20-mc-vc-PABC-MMAE ADC (ADC-187LZY)
• • Target: CD20
  • Linker: mc-VC-PABC (maleimidocaproyl valine-citrulline-p-aminobenzyl carbamoyl)
  • Drug: MMAE (monomethyl auristatin E)
  Compare

• Anti-CD20-mc-MMAF ADC (ADC-188LZY)
• • Target: CD20
  • Linker: mc (maleimidocaproyl)
  • Drug: MMAF (monomethyl auristatin F)
  Compare

• Anti-CD21 (clone THB-5)-SPP-DM1 ADC (ADC-189LZY)
• • Target: CD21
  • Linker: SPP(N-succinimidyl-4-(2-pyridyldithio)pentanoate)
  • Drug: DM1(N2'-deacetyl-N2'-(3-mercapto-1-oxopropyl)-maytansine)
  Compare

• Anti-CD21 (clone THB-5)-MCC-DM1 ADC (ADC-190LZY)
• • Target: CD21
  • Linker: MCC(Maleimidomethyl cyclohexane-1-carboxylate)
  • Drug: DM1(N2'-deacetyl-N2'-(3-mercapto-1-oxopropyl)-maytansine)
  Compare

• Anti-CD21 (clone THB-5)-mc-vc-PABC-MMAE ADC (ADC-191LZY)
• • Target: CD21
  • Linker: mc-VC-PABC(maleimidocaproyl valine-citrulline-p-aminobenzyl carbamoyl)
  • Drug: MMAE (monomethyl auristatin E)
  Compare

• Anti-CD21 (clone THB-5)-mc-MMAF ADC (ADC-192LZY)
• • Target: CD21
  • Linker: mc(maleimidocaproyl)
  • Drug: MMAF (monomethyl auristatin F)
  Compare

• Anti-CD22 (clone 10F4v3)-SPP-DM1 ADC (ADC-193LZY)
• • Target: CD22
  • Linker: SPP(N-succinimidyl-4-(2-pyridyldithio)pentanoate)
  • Drug: DM1(N2'-deacetyl-N2'-(3-mercapto-1-oxopropyl)-maytansine)
  Compare

• Anti-CD22 (clone 10F4v3)-MCC-DM1 ADC (ADC-194LZY)
• • Target: CD22
  • Linker: MCC(Maleimidomethyl cyclohexane-1-carboxylate)
  • Drug: DM1(N2'-deacetyl-N2'-(3-mercapto-1-oxopropyl)-maytansine)
  Compare

• Anti-CD22 (clone 10F4v3)-mc-vc-PABC-MMAE ADC (ADC-195LZY)
• • Target: CD22
  • Linker: mc-VC-PABC(maleimidocaproyl valine-citrulline-p-aminobenzyl carbamoyl)
  • Drug: MMAE (monomethyl auristatin E)
  Compare

• Anti-CD22 (clone 10F4v3)-mc-MMAF ADC (ADC-196LZY)
• • Target: CD22
  • Linker: mc(maleimidocaproyl)
  • Drug: MMAF (monomethyl auristatin F)
  Compare

• Anti-CD180 (clone MHR73-11)-SPP-DM1 ADC (ADC-197LZY)
• • Target: CD180
  • Linker: SPP(N-succinimidyl-4-(2-pyridyldithio)pentanoate)
  • Drug: DM1(N2'-deacetyl-N2'-(3-mercapto-1-oxopropyl)-maytansine)
  Compare

• Anti-CD180 (clone MHR73-11)-MCC-DM1 ADC (ADC-198LZY)
• • Target: CD180
  • Linker: MCC(Maleimidomethyl cyclohexane-1-carboxylate)
  • Drug: DM1(N2'-deacetyl-N2'-(3-mercapto-1-oxopropyl)-maytansine)
  Compare

• Anti-CD180 (clone MHR73-11)-mc-vc-PABC-MMAE ADC (ADC-199LZY)
• • Target: CD180
  • Linker: mc-VC-PABC(maleimidocaproyl valine-citrulline-p-aminobenzyl carbamoyl)
  • Drug: MMAE (monomethyl auristatin E)
  Compare

• Anti-CD180 (clone MHR73-11)-mc-MMAF ADC (ADC-200LZY)
• • Target: CD180
  • Linker: mc(maleimidocaproyl)
  • Drug: MMAF (monomethyl auristatin F)
  Compare

• Anti-CD79b (clone SN8)-SPP-DM1 ADC (ADC-201LZY)
• • Target: CD79b
  • Linker: SPP(N-succinimidyl-4-(2-pyridyldithio)pentanoate)
  • Drug: DM1(N2'-deacetyl-N2'-(3-mercapto-1-oxopropyl)-maytansine)
  Compare

• Anti-CD79b (clone SN8)-MCC-DM1 ADC (ADC-202LZY)
• • Target: CD79b
  • Linker: MCC(Maleimidomethyl cyclohexane-1-carboxylate)
  • Drug: DM1(N2'-deacetyl-N2'-(3-mercapto-1-oxopropyl)-maytansine)
  Compare

• Anti-CD79b (clone SN8)-mc-vc-PABC-MMAE ADC (ADC-203LZY)
• • Target: CD79b
  • Linker: mc-VC-PABC(maleimidocaproyl valine-citrulline-p-aminobenzyl carbamoyl)
  • Drug: MMAE (monomethyl auristatin E)
  Compare

• Anti-CD79b (clone SN8)-mc-MMAF ADC (ADC-204LZY)
• • Target: CD79b
  • Linker: mc(maleimidocaproyl)
  • Drug: MMAF (monomethyl auristatin F)
  Compare

• Anti-gp120-SPP-DM1 ADC (ADC-205LZY)
• • Target: gp120
  • Linker: SPP(N-succinimidyl-4-(2-pyridyldithio)pentanoate)
  • Drug: DM1(N2'-deacetyl-N2'-(3-mercapto-1-oxopropyl)-maytansine)
  Compare

• Anti-gp120-MCC-DM1 ADC (ADC-206LZY)
• • Target: gp120
  • Linker: MCC(Maleimidomethyl cyclohexane-1-carboxylate)
  • Drug: DM1(N2'-deacetyl-N2'-(3-mercapto-1-oxopropyl)-maytansine)
  Compare

• Anti-gp120-mc-vc-PABC-MMAE ADC (ADC-207LZY)
• • Target: gp120
  • Linker: mc-VC-PABC(maleimidocaproyl valine-citrulline-p-aminobenzyl carbamoyl)
  • Drug: MMAE (monomethyl auristatin E)
  Compare

• Anti-gp120-mc-MMAF ADC (ADC-208LZY)
• • Target: gp120
  • Linker: mc(maleimidocaproyl)
  • Drug: MMAF (monomethyl auristatin F)
  Compare

• Anti-CanAg (clone huC242)-SPP-DM1 ADC (ADC-209LZY)
• • Target: CanAg
  • Linker: SPP(N-succinimidyl 4-(2-pyridyldithio)pentanoate)
  • Drug: DM1(N2'-deacetyl-N2'-(3-mercapto-1-oxopropyl)-maytansine)
  Compare

• Anti-CanAg (clone huC242)-SMCC-DM1 ADC (ADC-210LZY)
• • Target: CanAg
  • Linker: SMCC (4-[N-maleimidomethyl] cyclohexane-1 carboxylhydrazide).
  • Drug: DM1(N2'-deacetyl-N2'-(3-mercapto-1-oxopropyl)-maytansine)
  Compare

• Anti-CanAg (clone huC242)-SPDB-DM4 ADC (ADC-211LZY)
• • Target: CanAg
  • Linker: SPDB(N-succinimidyl 4-(2-pyridyldithio)butyrate)
  • Drug: DM4(N2'-Deacetyl-N2'-(4-mercapto-4-methyl-1-oxopentyl)maytansine)
  Compare

• Anti-CanAg (clone huC242)-SPP-[3H]DM1 ADC (ADC-212LZY)
• • Target: CanAg
  • Linker: SPP(N-succinimidyl 4-(2-pyridyldithio)pentanoate)
  • Drug: [3H]DM1([3H]N2'-deacetyl-N2'-(3-mercapto-1-oxopropyl)-maytansine)
  Compare

• Anti-CanAg (clone huC242)-SMCC-[3H]DM1 ADC (ADC-213LZY)
• • Target: CanAg
  • Linker: SMCC (4-[N-maleimidomethyl] cyclohexane-1 carboxylhydrazide).
  • Drug: [3H]DM1([3H]N2'-deacetyl-N2'-(3-mercapto-1-oxopropyl)-maytansine)
  Compare

• Anti-CanAg (clone huC242)-SPDB-[3H]DM4 ADC (ADC-214LZY)
• • Target: CanAg
  • Linker: SPDB(N-succinimidyl 4-(2-pyridyldithio)butyrate)
  • Drug: [3H]DM4([3H]N2'-Deacetyl-N2'-(4-mercapto-4-methyl-1-oxopentyl)maytansine)
  Compare

• Anti-CD70 (clone h1F6 C4v2)-mc-C-labeled MMAF ADC (ADC-215LZY)
• • Target: CD70
  • Linker: mc (maleimidocaproyl)
  • Drug: C-labeled MMAF(C-labeled monomethylauristatin F)
  Compare

• Anti-cyCD79b (clone 10D10)-MCC-DM1 ADC (ADC-216LZY)
• • Target: cyCD79b
  • Linker: MCC(Maleimidomethyl cyclohexane-1-carboxylate))
  • Drug: DM1(N2'-deacetyl-N2'-(3-mercapto-1-oxopropyl)-maytansine)
  Compare

• Anti-MUC16 (clone ch11D10)-mc-MMAF ADC (ADC-217LZY)
• • Target: MUC16
  • Linker: mc (maleimidocaproyl)
  • Drug: MMAF (monomethyl auristatin F)
  Compare

• Anti-MUC16 (clone ch11D10)-vc-MMAF ADC (ADC-218LZY)
• • Target: MUC16
  • Linker: VC (valine-citrulline)
  • Drug: MMAF (monomethyl auristatin F)
  Compare

• Anti-mucin repeats (clone ch3A5)-mc-MMAF ADC (ADC-219LZY)
• • Target: mucin repeats
  • Linker: mc (maleimidocaproyl)
  • Drug: MMAF (monomethyl auristatin F)
  Compare

• Anti-mucin repeats (clone ch3A5)-vc-MMAF ADC (ADC-220LZY)
• • Target: mucin repeats
  • Linker: VC (valine-citrulline)
  • Drug: MMAF (monomethyl auristatin F)
  Compare

• Anti-Her2-vc-[14C]MMAE ADC (ADC-221LZY)
• • Target: Her2
  • Linker: VC(valine-citrulline)
  • Drug: [14C]MMAE(14C-labeled monomethyl auristatin E)
  Compare

• Anti-CD70 (clone 1F6)-mc-vc-PABC-MMAF ADC (ADC-222LZY)
• • Target: CD70
  • Linker: mc-VC-PABC(maleimidocaproyl valine-citrulline-p-aminobenzyl carbamoyl)
  • Drug: MMAF (monomethyl auristatin F)
  Compare

• Anti-CD70 (clone 1F6)-mc-MMAF ADC (ADC-223LZY)
• • Target: CD70
  • Linker: mc (maleimidocaproyl)
  • Drug: MMAF (monomethyl auristatin F)
  Compare

• Anti-MTf/p97 (clone L49)-vc-MMAF ADC (ADC-224LZY)
• • Target: MTf /p97
  • Linker: VC (valine-citrulline)
  • Drug: MMAF (monomethyl auristatin F)
  Compare

• Anti-MSLN (clone h7D9.v3)-mc-MMAF ADC (ADC-225LZY)
• • Target: MSLN
  • Linker: mc (maleimidocaproyl)
  • Drug: MMAF (monomethyl auristatin F)
  Compare

• Anti-MSLN (clone h7D9.v3)-mc-vc-PABC-MMAE ADC (ADC-226LZY)
• • Target: MSLN
  • Linker: mc-VC-PABC (maleimidocaproyl valine-citrulline-p-aminobenzyl carbamoyl)
  • Drug: MMAE (monomethyl auristatin E)
  Compare

• Anti-MSLN (clone h7D9.v3)-mc-vc-PABC-MMAF ADC (ADC-227LZY)
• • Target: MSLN
  • Linker: mc-VC-PABC (maleimidocaproyl valine-citrulline-p-aminobenzyl carbamoyl)
  • Drug: MMAF (monomethyl auristatin F)
  Compare

• Anti-RON (clone Zt/g4)-SMCC-DM1 ADC (ADC-228LZY)
• • Target: RON
  • Linker: SMCC (4-[N-maleimidomethyl] cyclohexane-1 carboxylhydrazide).
  • Drug: DM1(N2'-deacetyl-N2'-(3-mercapto-1-oxopropyl)-maytansine)
  Compare

• Anti-RON (clone Zt/c1)-SMCC-DM1 ADC (ADC-229LZY)
• • Target: RON
  • Linker: SMCC (4-[N-maleimidomethyl] cyclohexane-1 carboxylhydrazide).
  • Drug: DM1(N2'-deacetyl-N2'-(3-mercapto-1-oxopropyl)-maytansine)
  Compare

• Anti-LeY (clone hu3S193)-AcBut-CalichDMH ADC (ADC-230LZY)
• • Target: LeY
  • Linker: AcBut (4-(4-acetylphenoxy)butanoic acid)
  • Drug: CalichDMH
  Compare

• Anti-Her2-SPP-DM1 ADC (ADC-231LZY)
• • Target: Her2
  • Linker: SPP (N-succinimidyl 4-(2-pyridyldithio)pentanoate)
  • Drug: DM1(N2'-deacetyl-N2'-(3-mercapto-1-oxopropyl)-maytansine)
  Compare

• Anti-EGFR (ABT-806)-Mc-MMAE ADC (ABT-414) (ADC-L001)
• • Target: EGFR
  • Linker: Mc (maleimidocaproyl)
  • Drug: MMAF (Monomethyl auristatin F)
  Compare

• Anti-AGS-16 (AGS-16M7.8)-Mc-MMAF ADC (AGS-16M8F) (ADC-L003)
• • Target: AGS-16
  • Linker: Mc (maleimidocaproyl)
  • Drug: MMAF (Monomethyl auristatin F)
  Compare

• Anti-Nectin-4 (Enfortumab)-mc-val-cit-PABC-MMAE ADC (AGS-22ME) (ADC-L004)
• • Target: Nectin-4
  • Linker: mc-val-cit-PABC (cleavable maleimidocaproyl-valyl-citrullinyl-p-aminobenzyloxycarbonyl)
  • Drug: MMAE (Monomethyl auristatin E)
  Compare

• Anti-CD37 (AGS67C)-mc-val-cit-PABC-MMAE ADC (AGS67E) (ADC-L005)
• • Target: CD37
  • Linker: mc-val-cit-PABC (cleavable maleimidocaproyl-valyl-citrullinyl-p-aminobenzyloxycarbonyl)
  • Drug: MMAE (Monomethyl auristatin E)
  Compare

• Anti-SCL44A4-mc-vc-MMAE ADC (AGS-5ME) (ADC-L007)
• • Target: SCL44A4
  • Linker: mc-vc (maleimidocaproyl-valine-alanine)
  • Drug: MMAE (Monomethyl auristatin E)
  Compare

• Anti-CA6 (3ee9)-mc-vc-MMAE ADC (BAY-79-4620) (ADC-L008)
• • Target: CA6
  • Linker: mc-vc (maleimidocaproyl-valine-alanine)
  • Drug: MMAE (Monomethyl auristatin E)
  Compare

• Anti-Mesothelin (MF-T)-DM4 ADC (BAY 94-9343) (ADC-L009)
• • Target: mesothelin
  • Linker: disulfide
  • Drug: DM4 (N2'-Deacetyl-N2'-(4-mercapto-4- methyl-1-oxopentyl)maytansine)
  Compare

• Anti-CD-138 (nBT062)-SPDB-DM4 ADC (BT-062/indatuximab ravtansine) (ADC-L011)
• • Target: CD-138(=SDC1)
  • Linker: SPDB (N-succinimidyl 4-(2-pyridyldithio)butyrate)
  • Drug: DM4 (N2'-Deacetyl-N2'-(4-mercapto-4- methyl-1-oxopentyl)maytansine)
  Compare

• Anti-CD70 (MDX-1115)-Duocarmycins ADC (MDX-1203) (ADC-L012)
• • Target: CD70
  • Linker: cleavable di-peptide linker
  • Drug: Duocarmycins
  Compare

• Anti-Mesothelin (MDX-1382)-Duocarmycins ADC (MDX-1204) (ADC-L013)
• • Target: mesothelin
  • Linker: cleavable di-peptide linker
  • Drug: Duocarmycins
  Compare

• Anti-Tim-1 (CR014)-vc-MMAE ADC (CDX-014) (ADC-L014)
• • Target: Tim-1
  • Linker: vc (valine-citrulline)
  • Drug: MMAE (Monomethyl auristatin E)
  Compare

• Anti-Tissue factor (TF-011)-vc-MMAE ADC (HuMax-TF ADC) (ADC-L015)
• • Target: Tissue factor
  • Linker: vc (valine-citrulline)
  • Drug: MMAE (Monomethyl auristatin E)
  Compare

• Anti-EGFR (J2898A)-SMCC-DM1 ADC (IMGN289) (ADC-L016)
• • Target: EGFR
  • Linker: SMCC (N-succinimidyl 4-(Nmaleimidomethyl)cyclohexane-1-carboxylate)
  • Drug: DM1 (N2'-Deacetyl-N2'-(3-mercapto- 1-oxopropyl)maytansine)
  Compare

• Anti-CD56 (huN901)-SPP-DM1 ADC (IMGN901/Lorvotuzumab mertansine) (ADC-L017)
• • Target: CD56
  • Linker: SPP (N-succinimidyl-4-(2-pyridyldithio)pentanoate)
  • Drug: DM1 (N2'-Deacetyl-N2'-(3-mercapto- 1-oxopropyl)maytansine)
  Compare

• Anti-FOLR1 (Mirvetuximab)-sulfo-SPDB-DM4 ADC (IMGN853) (ADC-L018)
• • Target: FOLR1
  • Linker: sulfo-SPDB (sulfosuccinimidyl N-succinimidyl-4-(2-pyridyldithio)butyrate)
  • Drug: DM4 (N2'-Deacetyl-N2'-(4-mercapto-4- methyl-1-oxopentyl)maytansine)
  Compare

• Anti-CD37 (K7153A)-SMCC-DM1 ADC (IMGN529) (ADC-L019)
• • Target: CD37
  • Linker: SMCC (N-succinimidyl 4-(Nmaleimidomethyl)cyclohexane-1-carboxylate)
  • Drug: DM1 (N2'-Deacetyl-N2'-(3-mercapto- 1-oxopropyl)maytansine)
  Compare

• Anti-CD66e-Mc-SN-38 ADC (IMMU-130/-SN-38) (ADC-L020)
• • Target: CD66e
  • Linker: mc (maleimidocaproyl)
  • Drug: SN-38 (7-ethyl-10-hydroxycamptothecin)
  Compare

• Anti-EhpA2 (1C1)-Mc-MMAF ADC (MEDI-547) (ADC-L023)
• • Target: EhpA2
  • Linker: Mc (maleimidocaproyl)
  • Drug: MMAF (Monomethyl auristatin F)
  Compare

• Anti-CD22 (Inotuzumab)-calicheamicin ADC (CMC-544/inotuzumab ozogamicin) (ADC-L024)
• • Target: CD22
  • Linker: acetyl butyrate linker
  • Drug: calicheamicin
  Compare

• Anti-CD33 (hP67.6 )-calicheamicin ADC (gemtuzumab ozogamicin) (ADC-L025)
• • Target: CD33
  • Linker: acetyl butyrate linker
  • Drug: calicheamicin
  Compare

• Anti-STEAP1 (vandortuzumab )-mc-val-cit-PABC-MMAE ADC (RG7450) (ADC-L027)
• • Target: STEAP1
  • Linker: mc-val-cit-PABC (cleavable maleimidocaproyl-valyl-citrullinyl-p-aminobenzyloxycarbonyl)
  • Drug: MMAE (Monomethyl auristatin E)
  Compare

• Anti-CD22 (CR011)-vc-MMAE ADC (RG7593) (ADC-L028)
• • Target: CD22
  • Linker: vc (valine-citrulline)
  • Drug: MMAE (Monomethyl auristatin E)
  Compare

• Anti-CD79b (SN8)-vc-MMAE ADC (RG7596) (ADC-L029)
• • Target: CD79b
  • Linker: vc (valine-citrulline)
  • Drug: MMAE (Monomethyl auristatin E)
  Compare

• Anti-HER2 (Trastuzumab)-Mcc-DM1 ADC (RG3502/T-MD1) (ADC-L030)
• • Target: HER2
  • Linker: mcc (Maleimidomethyl cyclohexane-1- carboxylate)
  • Drug: DM1 (N2'-Deacetyl-N2'-(3-mercapto- 1-oxopropyl)maytansine)
  Compare

• Anti-CD33 (h2H12ec)-Mc-vc-PBD ADC (SGN-CD33A) (ADC-L033)
• • Target: CD33
  • Linker: mc-vc (maleimidocaproyl-valine-alanine)
  • Drug: pyrrolobenzodiazepine (PBD) dimers SGD-1882
  Compare

• Anti-CD19 (hBU12)-Mc-MMAF ADC (SGN-19A) (ADC-L034)
• • Target: CD19
  • Linker: Mc (maleimidocaproyl)
  • Drug: MMAF (Monomethyl auristatin F)
  Compare

• Anti-GCC (5F9)-mc-val-cit-PABC-MMAE ADC (MLN0264) (ADC-L035)
• • Target: GCC
  • Linker: mc-val-cit-PABC (cleavable maleimidocaproyl-valyl-citrullinyl-p-aminobenzyloxycarbonyl )
  • Drug: MMAE (Monomethyl auristatin E)
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• Anti-CD30 (Cac10)-mc-val-cit-PABC-MMAE ADC (SGN-35/brentuximab vedotin) (ADC-L036)
• • Target: CD30
  • Linker: mc-val-cit-PABC (cleavable maleimidocaproyl-valyl-citrullinyl-p-aminobenzyloxycarbonyl )
  • Drug: MMAE (Monomethyl auristatin E)
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• Anti-HER2 (Trastuzumab)-vc-Duocarmycins ADC (SYD983) (ADC-L038)
• • Target: HER2
  • Linker: vc (valine-citrulline)
  • Drug: Duocarmycins
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• Anti-cKit-maitansine ADC (LOP628) (ADC-L039)
• • Target: cKit
  • Linker: non-cleavable linker
  • Drug: maitansine
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• Anti-Zinc transporter LIV-1 (hLIV22)-vc-MMAE ADC (SGN-LIV1A ) (ADC-L040)
• • Target: zinc transporter LIV-1
  • Linker: vc (valine-citrulline)
  • Drug: MMAE (Monomethyl auristatin E)
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• Anti-CD19 (hBU12ec)-Mc-vc-PBD ADC (SGN-CD19B) (ADC-L041)
• • Target: CD19
  • Linker: mc-vc (maleimidocaproyl-valine-alanine)
  • Drug: pyrrolobenzodiazepine (PBD) dimers SGD-1882
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• Anti-DLL3 (Rovalpituzumab )-Mc-vc-PBD ADC (Rovalpituzumab tesirine) (ADC-L042)
• • Target: DLL3
  • Linker: mc-vc (maleimidocaproyl-valine-alanine)
  • Drug: pyrrolobenzodiazepine (PBD) dimer SCX
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• Human Anti-GPC3 Recombinant Soluble TCR (VD5) (scTCR-400ZP-S(P))
• • Species Reactivity: Human
  • Epitope: FVGEFFTDV
  • MHC: HLA-A2
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• Recombinant Human Anti-GPC3 Soluble TCR (VD5) (ZIP-Fos/ZIP-Jun) (VS-0622-YF1153)
• • Species Reactivity: Human
  • Epitope: FVGEFFTDV
  • MHC: HLA-A2
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• Recombinant Human Anti-GPC3 Soluble TCR (VD5) (C-Cys) (VS-0622-YF3861)
• • Species Reactivity: Human
  • Epitope: FVGEFFTDV
  • MHC: HLA-A2
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• Recombinant Human Anti-GPC3 Soluble TCR (VD5) (KIH) (VS-0622-YF6569)
• • Species Reactivity: Human
  • Epitope: FVGEFFTDV
  • MHC: HLA-A2
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