Recombinant Anti-ADORA2A Vesicular Antibody, EV Displayed (VS-0425-YC495)
CAT#: VS-0425-YC495
The Recombinant Anti-ADORA2A Vesicular Antibody, EV Displayed (VS-0425-YC495) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to ADORA2A-expressed cells or tissues. ADORA2A is a GPCR adenosine receptor that influences cardiac, cerebral, and immune functions. ADORA2A is implicated in inflammatory and neurodegenerative disorders and exhibits diverse transcript variants.
Gene Expression
Normal Tissue
Figure 1 Caudate nucleus
High expression
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/75997/166267_B_7_7_val_selected.jpg
Normal Tissue
Figure 2 Colon
Endocrine cells Staining: High Intensity: Strong Enterocytes -
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/75997/166267_A_8_3.jpg
Normal Tissue
Figure 3 Liver
Hepatocytes Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/75997/166267_A_9_4.jpg
Normal Tissue
Figure 4 Kidney
Cells in glomeruli Staining: Medium Intensity: Strong Quantity: <25%
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/75997/166267_A_8_5.jpg
Normal Tissue
Figure 5 Lymph node
Non-germinal center cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/75997/166267_A_7_8.jpg
RNA Expression
Figure 6 RNA cell line category: Cell line enhanced (Daudi, Karpas-707, RPMI-8226, SK-BR-3, U-266/70, U-266/84, U-698)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000128271-ADORA2A
❮
❯
Recombinant Antibody
- Application
- ELISA, FC, Cell-uptake
- Product Type
- Ab-Fc-EVs
- Antibody Quantification (Ab/EV)
- ~100 Ab/EV
- Target
- ADORA2A
- Host Animal
- Mouse
- Antibody Isotype
- IgG
- Species Reactivity
- Human
- Expression Cell
- Mammalian cell
Engineered EVs
- EV-sorting domain
- CD63
- Fc-binding domain
- Protein A
- EV Size
- 30~150 nm
- Producing Cell
- HEK293F
- Isolation Method
- Gradient centrifugation
- Purification
- qEV size exclusion chromatography
- Concentration
- 1 x 10¹⁰
- Size
- 1 mL
- Buffer
- PBS
- Storage
- Store at -80°C for 12 months
Target
- Full Name
- Adenosine A2a receptor
- Molecular Function
- G-protein coupled receptor, Receptor, Transducer
- Introduction
- This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor (GPCR) superfamily, which is subdivided into classes and subtypes. The receptors are seven-pass transmembrane proteins that respond to extracellular cues and activate intracellular signal transduction pathways. This protein, an adenosine receptor of A2A subtype, uses adenosine as the preferred endogenous agonist and preferentially interacts with the G(s) and G(olf) family of G proteins to increase intracellular cAMP levels. It plays an important role in many biological functions, such as cardiac rhythm and circulation, cerebral and renal blood flow, immune function, pain regulation, and sleep. It has been implicated in pathophysiological conditions such as inflammatory diseases and neurodegenerative disorders. Alternative splicing results in multiple transcript variants. A read-through transcript composed of the upstream SPECC1L (sperm antigen with calponin homology and coiled-coil domains 1-like) and ADORA2A (adenosine A2a receptor) gene sequence has been identified, but it is thought to be non-coding. [provided by RefSeq, Jun 2013]
- Alternative Names
- ADORA2, RDC8
- Gene ID
- 135
- UniProt ID
- P29274
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Datasheet
MSDS
COA
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-3693z | Mouse Anti-ADORA2A Recombinant Antibody (clone 31G2) | WB, IP, IF, IHC, ELISA | Mouse IgG2a, κ |
| PABL-006 | Mouse Anti-ADORA2A Recombinant Antibody (clone Ab2838) | WB, ELISA, IF, FuncS | Mouse IgG |
| HPAB-0046-WJ | Mouse Anti-ADORA2A Recombinant Antibody (HPAB-0046-WJ) | ELISA | Mouse IgG3, κ |
| HPAB-AP567-YC | Mouse Anti-ADORA2A Recombinant Antibody (HPAB-AP567-YC) | ELISA, FC | Mouse IgG2a, κ |
| VS7-HM45 | Mouse Anti-ADORA2A Recombinant Antibody (clone 6A6G11) | ICC, FCM | Mouse IgG2a |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PSBL-006 | Mouse Anti-ADORA2A Recombinant Antibody (clone Ab2838); scFv Fragment | WB, ELISA, IF, FuncS | Mouse scFv |
| HPAB-0046-WJ-S(P) | Mouse Anti-ADORA2A Recombinant Antibody; scFv Fragment (HPAB-0046-WJ-S(P)) | ELISA | Mouse scFv |
| HPAB-AP567-YC-S(P) | Mouse Anti-ADORA2A Recombinant Antibody; scFv Fragment (HPAB-AP567-YC-S(P)) | ELISA, FC | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PFBL-006 | Mouse Anti-ADORA2A Recombinant Antibody (clone Ab2838); Fab Fragment | WB, ELISA, IF, FuncS | Mouse Fab |
| HPAB-0046-WJ-F(E) | Mouse Anti-ADORA2A Recombinant Antibody; Fab Fragment (HPAB-0046-WJ-F(E)) | ELISA | Mouse Fab |
| HPAB-AP567-YC-F(E) | Mouse Anti-ADORA2A Recombinant Antibody; Fab Fragment (HPAB-AP567-YC-F(E)) | ELISA, FC | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-0089 | Hi-Affi™ Rabbit Anti-ADORA2A Recombinant Antibody (clone DS89AB) | WB | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY191 | Anti-ADORA2A Immunohistochemistry Kit | IHC |
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