Recombinant Anti-SLC4A1 Vesicular Antibody, EV Displayed (VS-0425-YC713)
CAT#: VS-0425-YC713
The Recombinant Anti-SLC4A1 Vesicular Antibody, EV Displayed (VS-0425-YC713) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to SLC4A1-expressed cells or tissues. SLC4A1 is an anion exchanger important for carbon dioxide transport in erythrocytes, with mutations linked to blood disorders and renal conditions.
Gene Expression
Normal Tissue
Figure 1 Bone marrow
High expression
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/15584/35065_B_4_4_val_selected.jpg
Normal Tissue
Figure 2 Cerebral cortex
Neuronal cells Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/15584/35065_B_7_5.jpg
Normal Tissue
Figure 3 Kidney
Distal tubules Staining: Medium Intensity: Strong Quantity: <25%
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/15584/35065_A_8_5.jpg
Normal Tissue
Figure 4 Testis
Leydig cells Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/15584/35065_A_5_6.jpg
RNA Expression
Figure 5 RNA cell line category: Cell line enhanced (K-562)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000004939-SLC4A1
❮
❯
Recombinant Antibody
- Application
- ELISA, FC, Cell-uptake
- Product Type
- Ab-Fc-EVs
- Antibody Quantification (Ab/EV)
- ~100 Ab/EV
- Target
- SLC4A1
- Host Animal
- Human
- Antibody Isotype
- IgG
- Species Reactivity
- Human
- Expression Cell
- Mammalian cell
Engineered EVs
- EV-sorting domain
- CD63
- Fc-binding domain
- z domain
- EV Size
- 30~150 nm
- Producing Cell
- HEK293F
- Isolation Method
- Gradient centrifugation
- Purification
- qEV size exclusion chromatography
- Binding Affinity
- Kd = 0.85 µg/mL
- Concentration
- 1 x 10¹⁰
- Size
- 1 mL
- Buffer
- PBS
- Storage
- Store at -80°C for 12 months
Target
- Full Name
- Solute carrier family 4 member 1 (Diego blood group)
- Biological Process
- Anion exchange, Ion transport, Transport
- Molecular Function
- Blood group antigen
- Introduction
- The protein encoded by this gene is part of the anion exchanger (AE) family and is expressed in the erythrocyte plasma membrane, where it functions as a chloride/bicarbonate exchanger involved in carbon dioxide transport from tissues to lungs. The protein comprises two domains that are structurally and functionally distinct. The N-terminal 40kDa domain is located in the cytoplasm and acts as an attachment site for the red cell skeleton by binding ankyrin. The glycosylated C-terminal membrane-associated domain contains 12-14 membrane spanning segments and carries out the stilbene disulphonate-sensitive exchange transport of anions. The cytoplasmic tail at the extreme C-terminus of the membrane domain binds carbonic anhydrase II. The encoded protein associates with the red cell membrane protein glycophorin A and this association promotes the correct folding and translocation of the exchanger. This protein is predominantly dimeric but forms tetramers in the presence of ankyrin. Many mutations in this gene are known in man, and these mutations can lead to two types of disease: destabilization of red cell membrane leading to hereditary spherocytosis, and defective kidney acid secretion leading to distal renal tubular acidosis. Other mutations that do not give rise to disease result in novel blood group antigens, which form the Diego blood group system. Southeast Asian ovalocytosis (SAO, Melanesian ovalocytosis) results from the heterozygous presence of a deletion in the encoded protein and is common in areas where Plasmodium falciparum malaria is endemic. One null mutation in this gene is known, resulting in very severe anemia and nephrocalcinosis.
- Alternative Names
- AE1, CD233, DI, EPB3, FR, RTA1A, SW, WD, WR
- Gene ID
- 6521
- UniProt ID
- P02730
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Datasheet
MSDS
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| PABL-335 | Mouse Anti-SLC4A1 Recombinant Antibody (clone CBL17Q) | WB, ELISA, FuncS | Mouse IgG |
| VS2-QX27 | Mouse Anti-SLC4A1 Recombinant Antibody (clone BRIC 155) | FC, IF, WB | Mouse IgG2b, κ |
| VS2-QX28 | Mouse Anti-SLC4A1 Recombinant Antibody (clone BRIC 132) | IB | Mouse IgG1, κ |
| VS2-QX29 | Mouse Anti-SLC4A1 Recombinant Antibody (clone BRIC 6) | FC, IF | Mouse IgG3, κ |
| VS2-QX30 | Rat Anti-SLC4A1 Recombinant Antibody (clone BRAC 17) | IB | Rat IgG2b, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PSBL-335 | Mouse Anti-SLC4A1 Recombinant Antibody (clone CBL17Q); scFv Fragment | WB, ELISA, FuncS | Mouse scFv |
| FAMAB-0302CQ-S(P) | Mouse Anti-SLC4A1 Recombinant Antibody (clone BIII.136); scFv Fragment | IP, WB, IF, ELISA | Mouse scFv |
| PSBS-0004 | Mouse Anti-SLC4A1 Recombinant Antibody (Clone 4201); scFv Fragment | ELISA, FuncS | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PFBL-335 | Mouse Anti-SLC4A1 Recombinant Antibody (clone CBL17Q); Fab Fragment | WB, ELISA, FuncS | Mouse Fab |
| FAMAB-0302CQ-F(E) | Mouse Anti-SLC4A1 Recombinant Antibody (clone BIII.136); Fab Fragment | IP, WB, IF, ELISA | Mouse Fab |
| PFBS-0004 | Mouse Anti-SLC4A1 Recombinant Antibody (Clone 4201); Fab Fragment | ELISA, FuncS | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-3305 | Hi-Affi™ Recombinant Rabbit Anti-SLC4A1 Monoclonal Antibody (DS3305AB) | WB | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| EPAF-0630CQ | Recombinant Mouse Anti-Human SLC4A1 Antibody (1C4) | ELISA | IgG |
| EPAF-0631CQ | Recombinant Mouse Anti-Human SLC4A1 Antibody (4A3) | ELISA | IgG |
| EPAF-0632CQ | Recombinant Mouse Anti-Human SLC4A1 Antibody (5H12) | ELISA | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-XY2094 | Anti-SLC4A1 Immunohistochemistry Kit | IHC | |
| VS-0525-XY6686 | Anti-Human SLC4A1 Immunohistochemistry Kit | IHC |
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