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αVβ3 integrin

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αVβ3 is an integrin and a receptor for vitronectin. It consists of two parts, integrin αV and integrin β3 (CD61), and is expressed by platelets. Furthermore, it is a receptor for phagocytosis on macrophages or dendritic cells. It is a member of the integrin superfamily of adhesion molecules. Thus, the 160/85 kDa heterodimeric protein exhibits many of the typical structural and functional features of integrins. It mediates adhesion of cells to extracellular matrices by recognizing the conserved arg-gly-asp (RGD) sequences of several plasma and matrix proteins. Recently, it has also been shown that αvβ3 is involved in signal transduction and cell-to-cell interaction. During angiogenesis and in certain types of malignancies, [alpha]v[beta]3 is highly expressed in bone resorbing cells, osteoclasts, and upregulated in response to vascular damage. Antagonists of αvβ3 are being developed for various diseases associated with altered receptor function or levels. Etaracizumab (trade name Abegrin) is a humanized monoclonal antibody that is being studied for the treatment of metastatic melanoma, prostate cancer, ovarian cancer and various other types of cancer.

Species Reactivity:
Human
Type:
Llama VHH
Application:
IP, ChiP, IHC, ELISA
Scaffold Name:
10-FnIII
Target:
αvβ3 Integrin
Species Reactivity:
Human
Derivation:
Phage display
Scaffold Name:
CTLA-4
Target:
αvβ3 integrin
Species Reactivity:
Human
Derivation:
Phage display
Scaffold Name:
Kunitz domains
Target:
αvβ3 integrin
Species Reactivity:
Human
Derivation:
Phage display
Scaffold Name:
RGD-containing proteins
Target:
αvβ3 Integrin
Species Reactivity:
Human
Derivation:
Phage display
Derivation:
Humanized (from mouse)
Species Reactivity:
Human
Type:
IgG2 - kappa
Application:
FC, IP, ELISA, Neut, FuncS, IF, IHC
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