αVβ3 integrin
αVβ3 is a type of integrin that is a receptor for vitronectin. It consists of two components, integrin alpha V and integrin beta 3 (CD61), and is expressed by platelets. Furthermore, it is a receptor for phagocytosis on macrophages or dendritic cells. Integrin αVβ3 is potential drug target because abnormal expression of v3 is linked to the development and progression of various diseases. Inhibitors like etaracizumab may be used as antiangiogenics.
Derivation: Humanized (from mouse)
Species Reactivity: Human
Type: IgG2 - kappa
Application: FC, IP, ELISA, Neut, FuncS, IF, IHC
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Derivation: Humanized
Species Reactivity: Human
Type: Humanized IgG1
Application: ELISA, Inhib, FC
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Derivation: Chimeric (mouse/human)
Species Reactivity: Human
Type: Chimeric (mouse/human) IgG1
Application: ELISA, Inhib, FC
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Species Reactivity: Human
Type: Mouse IgG1
Application: ELISA, Inhib, FC
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Derivation: Humanized
Species Reactivity: Human
Type: Humanized Fab
Application: ELISA
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Scaffold Name: CTLA-4
Target: αvβ3 integrin
Species Reactivity: Human
Derivation: Phage display
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Scaffold Name: 10-FnIII
Target: αvβ3 Integrin
Species Reactivity: Human
Derivation: Phage display
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Derivation: Humanized
Species Reactivity: Human
Type: Humanized IgG
Application: ELISA
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Scaffold Name: Kunitz domains
Target: αvβ3 integrin
Species Reactivity: Human
Derivation: Phage display
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Derivation: Humanized
Species Reactivity: Human
Type: Humanized scFv
Application: ELISA
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Scaffold Name: RGD-containing proteins
Target: αvβ3 Integrin
Species Reactivity: Human
Derivation: Phage display
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Derivation: Humanized (from mouse)
Species Reactivity: Human
Type: ADCC enhanced antibody
Application: FC, IP, ELISA, Neut, FuncS, IF
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For Research Use Only. Not For Clinical Use.