Anti-ACTG1 Recombinant Antibody Products

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Anti-ACTG1 Products

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For Research Use Only. Not For Clinical Use.

Creative Biolabs delivers premium recombinant antibodies targeting ACTG1, empowering breakthroughs in biomedical research through advanced scientific innovation. Leveraging our proprietary high-throughput platforms, we guarantee unparalleled product quality and consistency to meet the evolving demands of modern research. Our comprehensive portfolio of recombinant biologics is meticulously engineered to enhance experimental outcomes while ensuring reliability across diverse applications. Beyond supplying top-tier antibodies, we offer expert consultation and tailored technical assistance, supporting researchers from experimental design to data interpretation. Partnering with Creative Biolabs means accessing not only groundbreaking reagents but also a collaborative team committed to driving your scientific success forward with customized solutions and unwavering expertise.

ACTG1: A Multifaceted Player in Cancer Cardiovascular and Neurological Pathologies

ACTG1, a crucial cytoskeletal protein, plays a pivotal role in various disease mechanisms due to its involvement in cellular structure, motility, and signaling. Dysregulation of this protein has been linked to multiple pathological conditions, including cancer, cardiovascular disorders, and neurological diseases. In oncology, aberrant expression contributes to tumor progression by enhancing cell migration, invasion, and metastasis, making it a potential biomarker for aggressive malignancies. Cardiovascular research highlights its significance in maintaining vascular integrity, with mutations leading to impaired contractility and cardiomyopathy. Neurologically, defects are associated with developmental disorders and neurodegenerative diseases, where disrupted cytoskeletal dynamics impair synaptic function and neuronal stability. Additionally, its role in immune cell activation and inflammation implicates it in autoimmune and infectious diseases. Given its broad functional impact, therapeutic modulation holds promise for treating diverse conditions, though challenges remain in targeting it selectively without disrupting essential physiological processes. Ongoing research aims to elucidate its precise mechanisms in disease pathways, paving the way for novel interventions across multiple therapeutic areas.

Alternative Names

Complement Actin Gamma 1; ACTG; Deafness, Autosomal Dominant 20; Deafness, Autosomal Dominant 26; Epididymis Luminal Protein 176; Cytoskeletal Gamma-Actin; Actin, Cytoplasmic 2

Background

Actins are highly conserved proteins that are involved in various types of cell motility and in maintenance of the cytoskeleton. Three main groups of actin isoforms have been identified in vertebrate animals: alpha, beta, and gamma. The alpha actins are found in muscle tissues and are a major constituent of the contractile apparatus. The beta and gamma actins co-exist in most cell types as components of the cytoskeleton and as mediators of internal cell motility. Actin gamma 1, encoded by this gene, is a cytoplasmic actin found in all cell types. Mutations in this gene are associated with DFNA20/26, a subtype of autosomal dominant non-syndromic sensorineural progressive hearing loss and also with Baraitser-Winter syndrome. Alternative splicing results in multiple transcript variants.

Anti-ACTG1 rAb Products

To accelerate scientific progress, we provide premium-grade recombinant antibodies targeting ACTG1, combining superior performance with exceptional cost-efficiency. Our offerings are complemented by expert guidance and comprehensive technical assistance throughout your research journey.

Table 1. Featured anti-ACTG1 recombinant antibody products at Creative Biolabs.

Customer Reviews

Excellent

C**ss
Mouse Anti-ACTG1 Recombinant Antibody (clone 2A3) (CAT#: ZG-0977F)

We've been using this anti-ACTG1 antibody for about six months in our cardiac research. It gives consistent results in IF staining of human iPSC-derived cardiomyocytes, though we had to optimize the dilution to 1:200 for best results. The Western blot data looks clean with mouse brain homogenates, though we did observe some faint non-specific bands that didn't interfere with interpretation. What surprised me was how well it worked in co-IP experiments - pulled down ACTG1 nicely from HEK293T lysates. Haven't tried ELISA yet, but considering how it performs in other assays, I'd expect decent results.

17/Jun/2024

Excellent

Ju**r
Mouse Anti-ACTG1 Recombinant Antibody (VS3-CJ1066) (CAT#: VS3-CJ1066)

This VS3-CJ1066 clone has become our go-to for ACTG1 detection in neuronal studies. Works beautifully in WB with rat cortical neuron lysates, giving a crisp 42kDa band at 1:1000 dilution. Surprisingly effective in paraffin-embedded human glioma sections too - required antigen retrieval but gave clean nuclear/cytoplasmic staining. Saw some cross-reactivity in liver homogenates though, so tissue specificity might need verification. For the price, it's outperformed several other clones we've tested.

02/Dec/2023

rAb Production

With decades of specialized experience in antibody engineering and development, we've perfected streamlined processes to manufacture premium recombinant antibodies with exceptional consistency. Our optimized workflows enable rapid turnaround without compromising quality, supported by a customer-focused team dedicated to meeting your specific research requirements efficiently.

Featured Anti-ACTG1 Recombinant Antibody Production Platforms
Fig.1 Milligram-scale recombinant antibody production.

Fig.2 Gram-scale recombinant antibody production.

rAb Modalities

At Creative Biolabs, we specialize in developing cutting-edge antibody solutions across diverse formats to support groundbreaking research. Leveraging advanced protein engineering techniques and innovative design strategies, we provide meticulously crafted biologics that meet rigorous performance standards. Each product comes with personalized development support, ensuring optimal compatibility with your experimental requirements and research objectives.

Fig.3 Full Length Anti-ACTG1 Recombinant Antibody Production and Modalities.

For ACTG1-related inquiries, please don't hesitate to contact us through our available communication channels. Our specialists stand ready to provide comprehensive technical guidance and troubleshooting assistance throughout your investigation, guaranteeing you receive expert support for all your experimental needs.