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ARTC2
Loading...Anti-ARTC2 Products
- Camelid Anti-ARTC2 Recombinant Antibody (NABC-011)
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- Derivation: Llama
- Species Reactivity: Mouse
- Type: Camelid VHH
- Application: Block
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For Research Use Only. Not For Clinical Use.
Background
ARTC2, also known as ART2. 2, is a 35 kD, GPI-anchored, and cell surface ADPribosyltransferase that is highly expressed by regulatory T cells (Tregs) and natural killer T (NKT) cells. ARTC2 is enzymatically active at 4°C. Through the ribosylation of the ion channel P2X7, ARTC2 mediates NAD+-induced cell death (NICD) and the proteolytic shedding of CD27 and CD62L. Blocking the activity ARTC2 with Treg-Protector improves the recovery of Tregs and NKT cells during their isolation from lymphatic and peripheral tissues.