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BCL11A
Loading...Anti-BCL11A Products
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG2a, κ
- Application: ELISA, IHC, WB
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- Rabbit Anti-BCL11A Recombinant Antibody (clone JB35-68) (MRO-0398-CN)
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- Species Reactivity: Human
- Type: Rabbit IgG
- Application: WB, IHC, FC
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- Anti-BCL11A Immunohistochemistry Kit (VS-0325-XY230)
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- Species Reactivity: Human, Mouse, Rat
- Target: BCL11A
- Application: IHC
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- Anti-Mouse BCL11A Immunohistochemistry Kit (VS-0525-XY723)
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- Species Reactivity: Human, Mouse, Rat
- Target: BCL11A
- Application: IHC
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- Anti-Human BCL11A Immunohistochemistry Kit (VS-0525-XY722)
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- Species Reactivity: Human
- Target: BCL11A
- Application: IHC
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More Infomation
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For Research Use Only. Not For Clinical Use.
Background
This gene encodes a C2H2 type zinc-finger protein by its similarity to the mouse Bcl11a/Evi9 protein. The corresponding mouse gene is a common site of retroviral integration in myeloid leukemia, and may function as a leukemia disease gene, in part, through its interaction with BCL6. During hematopoietic cell differentiation, this gene is down-regulated. It is possibly involved in lymphoma pathogenesis since translocations associated with B-cell malignancies also deregulates its expression. Multiple transcript variants encoding several different isoforms have been found for this gene.
Protein class
Cancer-related genes, Disease related genes, Human disease related genes, Plasma proteins, Transcription factors
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Excitatory neurons, Inhibitory neurons, B-cells, dendritic cells, Squamous epithelial cells, Basal squamous epithelial cells)
Immune cell specificity
Group enriched (plasmacytoid DC, naive B-cell, memory B-cell)
Cell line specificity
Cell line enhanced (Daudi, MOLT-4, REH, U-698, U-937)
Interaction
Interacts with NR2F1, PIAS3, NR2F2 and NR2F6 (By similarity). Isoform 1, isoform 2 and isoform 3 form homodimers and heterodimers (PubMed:27453576). Isoform 2 interacts with TBR1 (PubMed:30250039).
Molecular function
Repressor
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