CytoStream™ Rabbit Anti-BCL11A Recombinant Antibody (VS13-YC94)
CAT#: VS13-YC94
The CytoStream™ Rabbit Anti-BCL11A Recombinant Antibody is specific for human BCL11A. BCL11A encodes a C2H2 zinc-finger protein potentially linked to leukemia as a retroviral integration site and is down-regulated during hematopoiesis, involved in lymphoma pathogenesis and producing multiple isoforms through alternative splicing. The anti-BCL11A antibody was developed and selected by our CytoStream™ platform and the mAb is recommended for use in flow cytometry staining (1/50-1/100).
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to nucleoplasm.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/29003/if_selected.jpg
Subcellular Location
Figure 2 IF staining of human cell line U-251 MG
Immunofluorescent staining of human cell line U-251 MG shows localization to nucleoplasm & nuclear bodies.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/14891/627_A2_2_selected.jpg
Normal Tissue
Figure 3 Tonsil
Germinal center cells Staining: Low Intensity: Weak Quantity:>75% Location: nuclear Non-germinal center cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Nuclear Squamous epithelial cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/29003/123908_A_6_8.jpg
Normal Tissue
Figure 4 Cerebral cortex
Neuronal cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/29003/123908_B_9_5.jpg
Normal Tissue
Figure 5 Kidney
Cells in tubules Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/29003/123908_A_8_5.jpg
RNA Expression
Figure 6 RNA cell line category: Cell line enhanced (Daudi, MOLT-4, REH, U-698, U-937)
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000119866-BCL11A
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Specifications
- Immunogen
- Recombinant human Ctip1, aa 381-609.
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human BCL11A
- Species Reactivity
- Human
- Applications
- WB, IHC-P, FC
- Conjugate
- NONE
- Related Disease
- Leukemia disease
Product Property
- Clonality
- Monoclonal
- Purification
- Protein A purified
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- TBS (pH 7.4) containing 40% Glycerol and 0.05% BSA.
- Preservative
- 0.05% Sodium azide
- Storage
- Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Shipping with ice pack.
Applications
- Application Notes
- Western blot (WB): 1/500-1/1000
Immunohistochemistry-paraffin (IHC-P): 1/50-1/800
Flow cytometry (FC): 1/50-1/100
Target
- Alternative Names
- B Cell CLL/Lymphoma 11A; Ecotropic Viral Integration Site 9 Protein Homolog; COUP-TF-Interacting Protein 1; Zinc Finger Protein 856; B-Cell CLL/Lymphoma 11A; ZNF856; CTIP1; EVI9; BCL11A B-Cell CLL/Lymphoma 11A (Zinc Finger Protein) Isoform 1; B-Cell CLL/Lymphoma 11A (Zinc Finger Protein) Isoform 2; B-Cell CLL/Lymphoma 11A (Zinc Finger Protein); Ecotropic Viral Integration Site 9 Homolog; Ecotropic Viral Integration Site 9;
- Gene ID
- 53335
- UniProt ID
- Q9H165
- Long Name
- B Cell CLL/Lymphoma 11A
- Cellular Localization
- Nucleus; Cytoplasm
- Protein Refseq
- XP_047300717.1; XP_024308731.1
- Function
- Transcription factor. Associated with the BAF SWI/SNF chromatin remodeling complex. Binds to the 5'-TGACCA-3' sequence motif in regulatory regions of target genes, including a distal promoter of the HBG1 hemoglobin subunit gamma-1 gene. Involved in regulation of the developmental switch from gamma- to beta-globin, probably via direct repression of HBG1; hence indirectly repressing fetal hemoglobin (HbF) level. Involved in brain development.
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Secondary Antibody
- CAT
- Product Name
Isotype Control
- CAT
- Product Name
See other products for "BCL11A"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-3986z | Mouse Anti-BCL11A Recombinant Antibody (clone 21H4) | ELISA, IHC, WB | Mouse IgG2a, κ |
| MRO-0398-CN | Rabbit Anti-BCL11A Recombinant Antibody (clone JB35-68) | WB, IHC, FC | Rabbit IgG |
| VS3-XY3275 | Rabbit Anti-BCL11A Recombinant Antibody (clone R07-2N7) | WB, IHC-P, ICC, IF, FC | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-XY230 | Anti-BCL11A Immunohistochemistry Kit | IHC | |
| VS-0525-XY723 | Anti-Mouse BCL11A Immunohistochemistry Kit | IHC | |
| VS-0525-XY722 | Anti-Human BCL11A Immunohistochemistry Kit | IHC |
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