CytoStream™ Rabbit Anti-BCL11A Recombinant Antibody (VS13-YC94) (CAT#: VS13-YC94)
The CytoStream™ Rabbit Anti-BCL11A Recombinant Antibody is specific for human BCL11A. BCL11A encodes a C2H2 zinc-finger protein potentially linked to leukemia as a retroviral integration site and is down-regulated during hematopoiesis, involved in lymphoma pathogenesis and producing multiple isoforms through alternative splicing. The anti-BCL11A antibody was developed and selected by our CytoStream™ platform and the mAb is recommended for use in flow cytometry staining (1/50-1/100).
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Custom Production
We specialize in custom recombinant antibody production, offering seamless execution from provided sequences to high-quality antibody deliverables, ensuring optimal yield and purity.
We require custom production
Subcellular Location
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line U-2 OS
(Immunofluorescent staining of human cell line U-2 OS shows localization to nucleoplasm.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/29003/if_selected.jpg
(Immunofluorescent staining of human cell line U-2 OS shows localization to nucleoplasm.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/29003/if_selected.jpg
Figure 2 IF staining of human cell line U-251 MG
(Immunofluorescent staining of human cell line U-251 MG shows localization to nucleoplasm & nuclear bodies.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/14891/627_A2_2_selected.jpg
(Immunofluorescent staining of human cell line U-251 MG shows localization to nucleoplasm & nuclear bodies.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/14891/627_A2_2_selected.jpg
Figure 3 Tonsil
(Germinal center cells Staining: Low Intensity: Weak Quantity:>75% Location: nuclear Non-germinal center cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Nuclear Squamous epithelial cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/29003/123908_A_6_8.jpg
(Germinal center cells Staining: Low Intensity: Weak Quantity:>75% Location: nuclear Non-germinal center cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Nuclear Squamous epithelial cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/29003/123908_A_6_8.jpg
Figure 4 Cerebral cortex
(Neuronal cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/29003/123908_B_9_5.jpg
(Neuronal cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/29003/123908_B_9_5.jpg
Figure 5 Kidney
(Cells in tubules Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/29003/123908_A_8_5.jpg
(Cells in tubules Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/29003/123908_A_8_5.jpg
Figure 6 RNA cell line category: Cell line enhanced (Daudi, MOLT-4, REH, U-698, U-937)
(Cell lines ordered by descending RNA expression order)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000119866-BCL11A
(Cell lines ordered by descending RNA expression order)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000119866-BCL11A
Specifications
- Immunogen
- Recombinant human Ctip1, aa 381-609.
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human BCL11A
- Species Reactivity
- Human
- Applications
- WB, IHC-P, FC
- Conjugate
- NONE
- Related Disease
- Leukemia disease
Product Property
- Clonality
- Monoclonal
- Purification
- Protein A purified
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- TBS (pH 7.4) containing 40% Glycerol and 0.05% BSA.
- Preservative
- 0.05% Sodium azide
- Storage
- Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Shipping with ice pack.
Applications
- Application Notes
- Western blot (WB): 1/500-1/1000
Immunohistochemistry-paraffin (IHC-P): 1/50-1/800
Flow cytometry (FC): 1/50-1/100
Target
- Alternative Names
- B Cell CLL/Lymphoma 11A; Ecotropic Viral Integration Site 9 Protein Homolog; COUP-TF-Interacting Protein 1; Zinc Finger Protein 856; B-Cell CLL/Lymphoma 11A; ZNF856; CTIP1; EVI9; BCL11A B-Cell CLL/Lymphoma 11A (Zinc Finger Protein) Isoform 1; B-Cell CLL/Lymphoma 11A (Zinc Finger Protein) Isoform 2; B-Cell CLL/Lymphoma 11A (Zinc Finger Protein); Ecotropic Viral Integration Site 9 Homolog; Ecotropic Viral Integration Site 9;
- Gene ID
- 53335
- UniProt ID
- Q9H165
- Long Name
- B Cell CLL/Lymphoma 11A
- Cellular Localization
- Nucleus; Cytoplasm
- Protein Refseq
- XP_047300717.1; XP_024308731.1
- Function
- Transcription factor. Associated with the BAF SWI/SNF chromatin remodeling complex. Binds to the 5'-TGACCA-3' sequence motif in regulatory regions of target genes, including a distal promoter of the HBG1 hemoglobin subunit gamma-1 gene. Involved in regulation of the developmental switch from gamma- to beta-globin, probably via direct repression of HBG1; hence indirectly repressing fetal hemoglobin (HbF) level. Involved in brain development.
Recommended Products
Secondary Antibody
Isotype Control
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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IgG Antibody Products
IHC Kit and Antibody Products: Precision Tools for Immunohistochemistry
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-3986z | Mouse Anti-BCL11A Recombinant Antibody (clone 21H4) | ELISA, IHC, WB | Mouse IgG2a, κ |
| MRO-0398-CN | Rabbit Anti-BCL11A Recombinant Antibody (clone JB35-68) | WB, IHC, FC | Rabbit IgG |
| VS3-XY3275 | Rabbit Anti-BCL11A Recombinant Antibody (clone R07-2N7) | WB, IHC-P, ICC, IF, FC | Rabbit IgG |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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