BUB1B

AbPlus Recombinant Antibody Products Formats

Anti-BUB1B Recombinant Antibody Products

Anti-BUB1B Immunohistochemistry Kit (VS-0325-XY269)
- Species Reactivity: Human, Mouse, Rat
- Target: BUB1B
- Application: IHC
Compare

Can't find the products you're looking for? Try to filter in the left sidebar.Filter By Tag

More Infomation

Our customer service representatives are available 24 hours a day, from Monday to Sunday. Contact Us

For Research Use Only. Not For Clinical Use.

This gene encodes a kinase involved in spindle checkpoint function. The protein has been localized to the kinetochore and plays a role in the inhibition of the anaphase-promoting complex/cyclosome (APC/C), delaying the onset of anaphase and ensuring proper chromosome segregation. Impaired spindle checkpoint function has been found in many forms of cancer.

Protein class

Cancer-related genes, Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets

Predicted location

Intracellular

Single cell type specificity

Cell type enhanced (Spermatocytes, Spermatogonia, Erythroid cells)

Immune cell specificity

Immune cell enhanced (naive B-cell)

Cell line specificity

Low cell line specificity

Interaction

Interacts with CENPE (PubMed:12925705, PubMed:19625775). Interacts with PLK1 (PubMed:16760428, PubMed:17785528, PubMed:17376779, PubMed:19503101). Part of a complex containing BUB3, CDC20 and BUB1B (PubMed:11702782). Interacts with anaphase-promoting complex/cyclosome (APC/C) (PubMed:10477750). Interacts with KNL1 (PubMed:17981135). Interacts with KAT2B (PubMed:19407811). Interacts with RIPK3 (PubMed:29883609). Interacts with the closed conformation form of MAD2L1 (PubMed:29162720).

Molecular function

Kinase, Serine/threonine-protein kinase, Transferase

More Types Infomation