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    BUB1B

    AbPlus Recombinant Antibody Products Formats

    Anti-BUB1B Recombinant Antibody Products

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    For Research Use Only. Not For Clinical Use.


    This gene encodes a kinase involved in spindle checkpoint function. The protein has been localized to the kinetochore and plays a role in the inhibition of the anaphase-promoting complex/cyclosome (APC/C), delaying the onset of anaphase and ensuring proper chromosome segregation. Impaired spindle checkpoint function has been found in many forms of cancer.
    Protein class

    Cancer-related genes, Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets

    Predicted location

    Intracellular

    Single cell type specificity

    Cell type enhanced (Spermatocytes, Spermatogonia, Erythroid cells)

    Immune cell specificity

    Immune cell enhanced (naive B-cell)

    Cell line specificity

    Low cell line specificity

    Interaction

    Interacts with CENPE (PubMed:12925705, PubMed:19625775). Interacts with PLK1 (PubMed:16760428, PubMed:17785528, PubMed:17376779, PubMed:19503101). Part of a complex containing BUB3, CDC20 and BUB1B (PubMed:11702782). Interacts with anaphase-promoting complex/cyclosome (APC/C) (PubMed:10477750). Interacts with KNL1 (PubMed:17981135). Interacts with KAT2B (PubMed:19407811). Interacts with RIPK3 (PubMed:29883609). Interacts with the closed conformation form of MAD2L1 (PubMed:29162720).

    Molecular function

    Kinase, Serine/threonine-protein kinase, Transferase

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