CARD8

AbPlus Formats

Anti-CARD8 Recombinant Antibody Products

Anti-CARD8 Immunohistochemistry Kit (VS-0325-XY317)
- Species Reactivity: Human, Mouse, Rat
- Target: CARD8
- Application: IHC
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For Research Use Only. Not For Clinical Use.

Inhibits NF-kappa-B activation. May participate in a regulatory mechanism that coordinates cellular responses controlled by NF-kappa-B transcription factor. May be a component of the inflammasome, a protein complex which also includes PYCARD, NALP2 and CASP1 and whose function would be the activation of proinflammatory caspases

Protein class

Human disease related genes

Predicted location

Intracellular

Single cell type specificity

Cell type enhanced (Adipocytes)

Immune cell specificity

Low immune cell specificity

Cell line specificity

Cell line enhanced (HEL, HUVEC TERT2, NB-4, TIME)

Interaction

Interacts with DPP9; leading to inhibit activation of the inflammasome (PubMed:31525884, PubMed:33731929, PubMed:34019797). DPP9 acts via formation of a ternary complex, composed of a DPP9 homodimer, one full-length CARD8 protein, and one cleaved C-terminus of CARD8 (Caspase recruitment domain-containing protein 8, C-terminus) (PubMed:34019797). Interacts with DPP8; leading to inhibit activation of the inflammasome, probably via formation of a ternary complex with DPP8 (PubMed:31525884). Interacts with NLRP3 (PubMed:24517500). Interacts with IKBKG/NEMO (PubMed:11551959). Interacts with DRAL (PubMed:12067710). Binds to caspase-1 (CASP1), CARD16/pseudo-ICE and CARD18/ICEBERG (PubMed:11821383). Interacts with NLRP2 (via NACHT domain) (PubMed:15030775). [Caspase recruitment domain-containing protein 8, N-terminus]: Interacts with the C-terminal part of CARD8 (Caspase recruitment domain-containing protein 8, C-terminus) in absence of pathogens and other damage-associated signals. [Caspase recruitment domain-containing protein 8, C-terminus]: Interacts with the N-terminal part of CARD8 (Caspase recruitment domain-containing protein 8, N-terminus) in absence of pathogens and other damage-associated signals (PubMed:33542150). Homomultimer; forms the CARD8 inflammasome polymeric complex, a filament composed of homopolymers of this form in response to pathogens and other damage-associated signals (PubMed:33420028, PubMed:33420033). The CARD8 inflammasome polymeric complex directly recruits pro-caspase-1 (proCASP1) independently of PYCARD/ASC (PubMed:32051255). Interacts (via CARD domain) with CASP1 (via CARD domain); leading to CASP1 activation (PubMed:33542150, PubMed:33420033).

Molecular function

Hydrolase, Protease

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