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CCNB2

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For Research Use Only. Not For Clinical Use.


Cyclin B2 is a member of the cyclin family, specifically the B-type cyclins. The B-type cyclins, B1 and B2, associate with p34cdc2 and are essential components of the cell cycle regulatory machinery. B1 and B2 differ in their subcellular localization. Cyclin B1 co-localizes with microtubules, whereas cyclin B2 is primarily associated with the Golgi region. Cyclin B2 also binds to transforming growth factor beta RII and thus cyclin B2/cdc2 may play a key role in transforming growth factor beta-mediated cell cycle control.
Protein class

Cancer-related genes, Plasma proteins, Transporters

Predicted location

Intracellular

Single cell type specificity

Cell type enhanced (Spermatocytes, Early spermatids, Extravillous trophoblasts, Erythroid cells, Cytotrophoblasts)

Immune cell specificity

Immune cell enriched (T-reg)

Cell line specificity

Low cell line specificity

Interaction

Interacts with the CDK1 protein kinase to form a serine/threonine kinase holoenzyme complex also known as maturation promoting factor (MPF). The cyclin subunit imparts substrate specificity to the complex.

Molecular function

Cyclin

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