Anti-CHKB Products

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For Research Use Only. Not For Clinical Use.

Creative Biolabs offers top-quality anti-CHKB recombinant antibodies, enabling research into muscular dystrophy. Choline Kinase Beta (CHKB), the beta isoform of choline kinase, has an essential and non-redundant role in maintaining the muscle membrane. Our recombinant antibodies are uniquely isoform-specific, providing critical reagents to support the research into the molecular causes of congenital muscular dystrophy and the role of phospholipid metabolism in muscle.

CHKB: A Choline Kinase Essential for Muscle Integrity

CHKB (choline kinase beta) is the second isoform of choline kinase, an enzyme responsible for the first committed step of phosphatidylcholine (PC) biosynthesis. CHKA is the alpha isoform and is expressed in all tissues, and is upregulated and highly active in most cancers, while CHKB is more restricted in expression and has a highly non-redundant role in specific tissues, most importantly skeletal muscle. CHKB activity is essential for both maintenance and repair of the muscle cell membrane (sarcolemma). Mutations that inactivate the CHKB gene lead to a very rare form of congenital muscular dystrophy (CMD) with symptoms of muscle weakness, developmental delay, and high creatine kinase levels.

Alternative Names

CHKB; CHETK; Choline/Ethanolamine Kinase; CKEKB; EK; Choline/Ethanolamine Kinase Beta; EC 2.7.1.32; EKB; Choline Kinase-Like Protein; EC 2.7.1.82; CKB; CK; CHKL; MDCMC; Choline Kinase Beta

Background

Choline kinase (CK) and ethanolamine kinase (EK) catalyze the phosphorylation of choline/ethanolamine to phosphocholine/phosphoethanolamine. This is the first enzyme in the biosynthesis of phosphatidylcholine/phosphatidylethanolamine in all animal cells. The highly purified CKs from mammalian sources and their recombinant gene products have been shown to have EK activity also, indicating that both activities reside on the same protein. The choline kinase-like protein encoded by CHKL belongs to the choline/ethanolamine kinase family; however, its exact function is not known. Read-through transcripts are expressed from this locus that include exons from the downstream CPT1B locus.

Anti-CHKB rAb Products

Creative Biolabs’ anti-CHKB recombinant antibodies are developed using state-of-the-art technology to achieve the highest possible isoform specificity. Rigorous validation has shown that this antibody reliably detects the beta isoform with no cross-reactivity to the highly homologous alpha isoform, CHKA. This is of particular importance for the accurate study of its distinct role in muscle. Our anti-CHKB rAbs have been optimized for Western Blot of muscle lysates as well as IHC of muscle biopsies, making our antibodies leading reagents for the study of neuromuscular disease.

Table 1. Featured anti-CHKB recombinant antibody products at Creative Biolabs.

Customer Reviews

rAb Production

Creative Biolabs is proud to leverage advanced technology for the production of its recombinant antibodies, and this is also the case for our anti-CHKB rAbs. Each antibody is developed with a focus on providing the highest possible level of isoform specificity and sensitivity for detection of this important metabolic enzyme.

Featured Anti-CHKB Recombinant Antibody Production Platforms
Fig.1 Milligram-scale anti-CHKB recombinant antibody production.

Fig.2 Gram-scale anti-CHKB recombinant antibody production.

rAb Modalities

Creative Biolabs is committed to providing researchers with flexible and creative antibody formats for your research. Our antibodies are available in a wide range of modalities to support a diverse range of experimental approaches for the study of CHKB.

Fig.3 Full-length anti-CHKB recombinant antibody production and modalities.

Partner with Creative Biolabs for the best anti-CHKB recombinant antibodies and drive progress in your muscular dystrophy research. Creative’s portfolio of anti-CHKB antibodies are known for their exceptional specificity and rigorous validation, providing the ideal reagents for your drug discovery and fundamental muscle biology experiments. Trust Creative to power your important work. Speak with one of our experts today.