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CLIP2
Anti-CLIP2 Recombinant Antibody Products
- Anti-CLIP2 Immunohistochemistry Kit (VS-0325-XY471)
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- Species Reactivity: Human, Mouse, Rat
- Target: CLIP2
- Application: IHC
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For Research Use Only. Not For Clinical Use.
The protein encoded by this gene belongs to the family of cytoplasmic linker proteins, which have been proposed to mediate the interaction between specific membranous organelles and microtubules. This protein was found to associate with both microtubules and an organelle called the dendritic lamellar body. This gene is hemizygously deleted in Williams syndrome, a multisystem developmental disorder caused by the deletion of contiguous genes at 7q11.23. Alternative splicing of this gene generates 2 transcript variants. [provided by RefSeq, Jul 2008]
Protein class
Human disease related genes, Plasma proteins
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Oligodendrocytes, Oligodendrocyte precursor cells, Excitatory neurons, Distal enterocytes)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Cell line enhanced (GAMG)
Interaction
Interacts with CLASP1 and CLASP2 (PubMed:11290329). Binds preferentially to tyrosinated microtubules, and only marginally to detyrosinated microtubules (By similarity).
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