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CNOT7
Anti-CNOT7 Recombinant Antibody Products
- Recombinant Mouse Anti-Human CNOT7 Antibody (MOB-1124MZ)
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- Species Reactivity: Human
- Type: Mouse antibody
- Application: WB
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- AbPlus™ Anti-CNOT7 Magnetic Beads (VS-0724-YC772) (VS-0724-YC772)
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- Target: CNOT7
- Target Species: Human
- Application: IP, Protein Purification
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For Research Use Only. Not For Clinical Use.
CNOT7 (CCR4-NOT Transcription Complex Subunit 7) is a Protein Coding gene. Among its related pathways are Cyclins and Cell Cycle Regulation and Gene Expression. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and RNA binding. An important paralog of this gene is CNOT8.
Protein class
Enzymes
Predicted location
Intracellular
Single cell type specificity
Low cell type specificity
Immune cell specificity
Low immune cell specificity
Cell line specificity
Low cell line specificity
Interaction
Component of the CCR4-NOT complex; distinct complexes seem to exist that differ in the participation of probably mutually exclusive catalytic subunits; the complex contains two deadenylase subunits, CNOT6 or CNOT6L, and CNOT7 or CNOT8 (PubMed:19558367). In the complex, interacts directly with CNOT1 (PubMed:21336257). Interacts with AGO2 (By similarity). Interacts with TOB1; recruited by TOB1 to a ternary complex with CPEB3 which is required for mRNA deadenylation and decay (PubMed:21336257, PubMed:23236473, PubMed:19276069). Interacts with BTG1 (By similarity). Interacts with BTG2 (PubMed:23236473). Interacts with NANOS2 (By similarity). Interacts with ZFP36, ZFP36L1 and ZFP36L2; these interactions are inhibited in response to phorbol 12-myristate 13-acetate (PMA) treatment in a p38 MAPK-dependent manner (PubMed:25106868). Interacts with TARDBP (PubMed:30520513). Interacts with BTG4 (PubMed:32502391). Interacts with EIF4E; this interaction is increased by CNOT7 interaction with BTG4 (By similarity).
Molecular function
Exonuclease, Hydrolase, Nuclease, Repressor, RNA-binding
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