DGKQ

AbPlus Formats

Anti-DGKQ Recombinant Antibody Products

Anti-DGKQ Immunohistochemistry Kit (VS-0325-XY655)
- Species Reactivity: Human, Mouse, Rat
- Target: DGKQ
- Application: IHC
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For Research Use Only. Not For Clinical Use.

The protein encoded by this gene contains three cysteine-rich domains, a proline-rich region, and a pleckstrin homology domain with an overlapping Ras-associating domain. It is localized in the speckle domains of the nucleus, and mediates the regeneration of phosphatidylinositol (PI) from diacylglycerol in the PI-cycle during cell signal transduction.

Protein class

Enzymes, Metabolic proteins, Plasma proteins

Predicted location

Intracellular

Single cell type specificity

Cell type enhanced (Distal enterocytes, Paneth cells, Proximal enterocytes, Intestinal goblet cells)

Immune cell specificity

Low immune cell specificity

Cell line specificity

Low cell line specificity

Interaction

Interacts with RHOA (constitutively activated, GTP-bound); the interaction inhibits DGKQ (PubMed:11309392, PubMed:15164764). Interacts with PRKCE (PubMed:15632189). Interacts with PRKCH (PubMed:15632189). Interacts with PLCB1 (PubMed:12799190). Interacts with NR5A1; the interaction requires both LXXLL motifs in DGKQ and is required for full phosphatidic acid-mediated activation of NR5A1 (PubMed:17664281).

Molecular function

Kinase, Transferase

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