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FYN
Anti-FYN Recombinant Antibody Products
- Mouse Anti-FYN Recombinant Antibody (clone 2H8) (VS3-XY751)
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- Species Reactivity: Human
- Type: Mouse IgG1
- Application: ELISA, WB
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- Mouse Anti-FYN Recombinant Antibody (clone 2A10) (VS3-QX452)
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: WB, IHC, ICC, FC, ELISA
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- Derivation: Mouse
- Species Reactivity: Human, Monkey, Rat, Mouse
- Type: Mouse IgG2b
- Application: WB, ICC
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- Rabbit Anti-FYN Polyclonal Antibody (MRO-1879-CN) (MRO-1879-CN)
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- Species Reactivity: Human, Mouse, Rat
- Type: Rabbit IgG
- Application: WB, IF, IHC, FC
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- Recombinant Mouse Anti-Human FYN Antibody (MOB-2419MZ)
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- Species Reactivity: Human
- Type: Mouse antibody
- Application: ELISA, WB
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For Research Use Only. Not For Clinical Use.
This gene is a member of the protein-tyrosine kinase oncogene family. It encodes a membrane-associated tyrosine kinase that has been implicated in the control of cell growth. The protein associates with the p85 subunit of phosphatidylinositol 3-kinase and interacts with the fyn-binding protein. Alternatively spliced transcript variants encoding distinct isoforms exist.
Protein class
Enzymes, Metabolic proteins, Plasma proteins
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Astrocytes, Oligodendrocyte precursor cells, dendritic cells, T-cells, NK-cells, Proximal tubular cells)
Immune cell specificity
Low immune cell specificity
Cell line specificity
Cell line enhanced (U-2197)
Interaction
Interacts (via its SH3 domain) with PIK3R1 and PRMT8. Interacts with FYB1, PAG1, and SH2D1A. Interacts with CD79A (tyrosine-phosphorylated form); the interaction increases FYN activity. Interacts (via SH2 domain) with CSF1R (tyrosine phosphorylated) (By similarity). Interacts with TOM1L1 (phosphorylated form). Interacts with KDR (tyrosine phosphorylated). Interacts (via SH3 domain) with KLHL2 (via N-terminus) (By similarity). Interacts with SH2D1A and SLAMF1. Interacts with ITCH; the interaction phosphorylates ITCH and negatively regulates its activity. Interacts with FASLG. Interacts with RUNX3. Interacts with KIT. Interacts with EPHA8; possible downstream effector of EPHA8 in regulation of cell adhesion. Interacts with PTK2/FAK1; this interaction leads to PTK2/FAK1 phosphorylation and activation. Interacts with CAV1; this interaction couples integrins to the Ras-ERK pathway. Interacts with UNC119. Interacts (via SH2 domain) with PTPRH (phosphorylated form) (By similarity). Interacts with PTPRO (phosphorylated form) (By similarity). Interacts with PTPRB (phosphorylated form) (By similarity). Interacts with FYB2 (PubMed:27335501). Interacts with DSCAM (By similarity). Interacts with SKAP1 and FYB1; this interaction promotes the phosphorylation of CLNK (By similarity). (Microbial infection) Interacts (via its SH3 domain) with hepatitis E virus/HEV protein ORF3.
Molecular function
Developmental protein, Kinase, Transferase, Tyrosine-protein kinase
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Related Signaling Pathways
FcεR1 Signaling Pathway