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    GABRA5

    AbPlus Recombinant Antibody Products Formats

    Anti-GABRA5 Recombinant Antibody Products

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    For Research Use Only. Not For Clinical Use.


    GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. At least 16 distinct subunits of GABA-A receptors have been identified. Transcript variants utilizing three different alternative non-coding first exons have been described.
    Protein class

    Disease related genes, FDA approved drug targets, Human disease related genes

    Predicted location

    Intracellular, Membrane (different isoforms)

    Single cell type specificity

    Group enriched (Excitatory neurons, Inhibitory neurons)

    Immune cell specificity

    Not detected in immune cells

    Cell line specificity

    Group enriched (A549, HAP1, NTERA-2, U-2 OS)

    Interaction

    Generally pentameric. There are five types of GABA(A) receptor subunits: alpha, beta, gamma, delta, and rho.

    Molecular function

    Chloride channel, Ion channel, Ligand-gated ion channel, Receptor

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