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GABRA5
Anti-GABRA5 Recombinant Antibody Products
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For Research Use Only. Not For Clinical Use.
GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. At least 16 distinct subunits of GABA-A receptors have been identified. Transcript variants utilizing three different alternative non-coding first exons have been described.
Protein class
Disease related genes, FDA approved drug targets, Human disease related genes
Predicted location
Intracellular, Membrane (different isoforms)
Single cell type specificity
Group enriched (Excitatory neurons, Inhibitory neurons)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Group enriched (A549, HAP1, NTERA-2, U-2 OS)
Interaction
Generally pentameric. There are five types of GABA(A) receptor subunits: alpha, beta, gamma, delta, and rho.
Molecular function
Chloride channel, Ion channel, Ligand-gated ion channel, Receptor
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