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For Research Use Only. Not For Clinical Use.


This gene encodes an incretin hormone and belongs to the glucagon superfamily. The encoded protein is important in maintaining glucose homeostasis as it is a potent stimulator of insulin secretion from pancreatic beta-cells following food ingestion and nutrient absorption. This gene stimulates insulin secretion via its G protein-coupled receptor activation of adenylyl cyclase and other signal transduction pathways. It is a relatively poor inhibitor of gastric acid secretion.
Protein class

Plasma proteins

Predicted location

Secreted

Single cell type specificity

Cell type enriched (Intestinal goblet cells)

Immune cell specificity

Not detected in immune cells

Cell line specificity

Group enriched (A549, BEWO, Hep G2)

Molecular function

Hormone

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