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GPR37
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For Research Use Only. Not For Clinical Use.
Background
This gene is a member of the G protein-coupled receptor family. The encoded protein contains seven transmembrane domains and is found in cell and endoplasmic reticulum membranes. G protein-coupled receptors are involved in translating outside signals into G protein mediated intracellular effects. This gene product interacts with Parkin and is involved in juvenile Parkinson disease.
Protein class
G-protein coupled receptors, Transporters
Predicted location
Membrane
Single cell type specificity
Group enriched (Muller glia cells, Oligodendrocytes)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Cell line enhanced (AF22, fHDF/TERT166, hTCEpi, SK-BR-3, SuSa, TIME)
Interaction
Forms a complex with PRKN, STUB1 and HSP70. The amount of STUB1 in the complex increases during ER stress. STUB1 promotes the dissociation of HSP70 from PRKN, thus facilitating PRKN-mediated GPR37 ubiquitination. Interacts with PACRG.
Molecular function
G-protein coupled receptor, Receptor, Transducer
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