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GRM5
Anti-GRM5 Recombinant Antibody Products
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For Research Use Only. Not For Clinical Use.
This gene encodes a member of the G-protein coupled receptor 3 protein family. The encoded protein is a metabatropic glutamate receptor, whose signaling activates a phosphatidylinositol-calcium second messenger system. This protein may be involved in the regulation of neural network activity and synaptic plasticity. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions.
Protein class
FDA approved drug targets, G-protein coupled receptors, Transporters
Predicted location
Intracellular, Membrane (different isoforms)
Single cell type specificity
Group enriched (Oligodendrocyte precursor cells, Inhibitory neurons, Excitatory neurons)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Not detected
Interaction
The PPXXF motif binds HOMER1, HOMER2 and HOMER3. Interacts with SIAH1, RYR1, RYR2, ITPR1, SHANK1, SHANK3 and TAMALIN. Interacts with NCDN (By similarity). Isoform 2 interacts with NECAB2 (PubMed:19694902). Interacts with CAMK2A (PubMed:28130356).
Molecular function
G-protein coupled receptor, Receptor, Transducer
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