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HES1
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Anti-HES1 Products
- Anti-Mouse HES1 Immunohistochemistry Kit (VS-0525-XY3119)
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- Species Reactivity: Human, Mouse, Rat
- Target: HES1
- Application: IHC
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- Anti-Rat HES1 Immunohistochemistry Kit (VS-0525-XY3120)
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- Species Reactivity: Human, Mouse, Rat
- Target: HES1
- Application: IHC
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More Infomation
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For Research Use Only. Not For Clinical Use.
Background
This protein belongs to the basic helix-loop-helix family of transcription factors. It is a transcriptional repressor of genes that require a bHLH protein for their transcription. The protein has a particular type of basic domain that contains a helix interrupting protein that binds to the N-box rather than the canonical E-box.
Protein class
Plasma proteins, Transcription factors
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Muller glia cells, Paneth cells, Undifferentiated cells, Hepatic stellate cells)
Immune cell specificity
Immune cell enriched (eosinophil)
Cell line specificity
Cell line enhanced (hTCEpi, OE19, SK-BR-3)
Interaction
Transcription repression requires formation of a complex with a corepressor protein of the Groucho/TLE family. Interacts (via WPRW motif) with TLE1, and more weakly with TLE2. Interacts with HES6 (By similarity). Interacts with SIRT1. Interacts with an FA complex, composed of FANCA, FANCF, FANCG and FANCL, but not of FANCC, nor FANCE.
Molecular function
DNA-binding, Repressor
More Types Infomation
Related Diseases
Breast Cancer