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HJURP
Anti-HJURP Recombinant Antibody Products
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For Research Use Only. Not For Clinical Use.
HJURP (Holliday Junction Recognition Protein) is a Protein Coding gene. Diseases associated with HJURP include Fibrillary Astrocytoma. Among its related pathways are Chromosome Maintenance and DNA Damage. Gene Ontology (GO) annotations related to this gene include identical protein binding and histone binding.
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Erythroid cells, Spermatocytes, Early spermatids, Spermatogonia, Extravillous trophoblasts, Granulosa cells)
Immune cell specificity
Immune cell enhanced (T-reg)
Cell line specificity
Low cell line specificity
Interaction
Interacts with CENPA (via CATD domain); the interaction is direct and specific for CENPA since it does not interact with H3.1- or H3.3-containing nucleosomes (PubMed:16622419, PubMed:19410544, PubMed:19410545). Heterotrimer composed of HJURP, CENPA and histone H4, where HJURP interacts with the dimer formed by CENPA and histone H4 and prevents tetramerization of CENPA and H4 (PubMed:21478274). Identified in a centromere complex containing histones H2A, H2B and H4, and at least CENPA, CENPB, CENPC, CENPT, CENPN, HJURP, SUPT16H, SSRP1 and RSF1 (PubMed:27499292). Interacts with 14-3-3 family members in a phosphorylation-dependent manner (PubMed:17256767). Interacts with MSH5 and NBN (PubMed:17823411).
Molecular function
Chaperone, DNA-binding
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