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For Research Use Only. Not For Clinical Use.
Enzymes, Plasma proteins, RAS pathway related proteins
Intracellular
Cell type enhanced (Excitatory neurons, Inhibitory neurons, Collecting duct cells, Oligodendrocyte precursor cells)
Not detected in immune cells
Cell line enhanced (HUVEC TERT2, SCLC-21H, TIME)
Heterodimerizes (via N-terminus) with BRAF (via N-terminus) in a MAP2K1/MEK1-dependent manner (PubMed:29433126). Interacts with BRAF; this increases the low intrinsic protein kinase activity of KSR2 (PubMed:21441910). Interacts with MAP2K1, forming a heterodimer that can dimerize to form a heterotetramer (PubMed:29433126, PubMed:21441910, PubMed:12975377). Interacts with MAP3K8, MAPK, RAS and RAF (PubMed:12975377).
Kinase, Serine/threonine-protein kinase, Transferase