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For Research Use Only. Not For Clinical Use.
Disease related genes, Human disease related genes
Intracellular, Membrane (different isoforms)
Cell type enhanced (Langerhans cells)
Immune cell enriched (neutrophil)
Low cell line specificity
Monomer (PubMed:27927196). Interacts with NEDD4 (PubMed:16118794, 27927196). Interacts (via PSAP motif) with TSG101, a component of the ESCRT-I complex (endosomal sorting complex required for transport I) (PubMed:16118794). Interacts with WWOX (PubMed:15064722). Interacts with STAM, a component of the ESCRT-0 complex; the interaction is direct (PubMed:23166352). Identified in a complex with STAM and HGS; within this complex, interacts directly with STAM, but not with HGS (PubMed:23166352). Interacts with STAT6 (PubMed:15793005).
DNA-binding