+ Filter

LMNA

Anti-LMNA Products

PE-A*02:01/Human LMNA (RLAVYIDRV) MHC Tetramer (MHC-LC1922)
- Class: Class I
- Antigen: LMNA
- Antigen Species: Human
- Peptide: RLAVYIDRV
- Conjugate: PE
Compare

APC-B*58:01/Human Lamin (KAGQVVTIW) MHC Tetramer (MHC-CN0129)
- Class: Class I
- Antigen: Lamin
- Antigen Species: Human
- Peptide: KAGQVVTIW
- Conjugate: APC
Compare

PE-B*58:01/Human Lamin (KAGQVVTIW) MHC Tetramer (MHC-CN0130)
- Class: Class I
- Antigen: Lamin
- Antigen Species: Human
- Peptide: KAGQVVTIW
- Conjugate: PE
Compare

More Infomation

Can't find the products you're looking for? Try to filter in the left sidebar.Filter By Tag

More Infomation

Our customer service representatives are available 24 hours a day, from Monday to Sunday. Contact Us

For Research Use Only. Not For Clinical Use.

The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. Alternative splicing results in multiple transcript variants. Mutations in this gene lead to several diseases: Emery-Dreifuss muscular dystrophy, familial partial lipodystrophy, limb girdle muscular dystrophy, dilated cardiomyopathy, Charcot-Marie-Tooth disease, and Hutchinson-Gilford progeria syndrome.

Protein class

Cancer-related genes, Disease related genes, Human disease related genes, Plasma proteins

Predicted location

Intracellular

Single cell type specificity

Cell type enhanced (Langerhans cells)

Immune cell specificity

Immune cell enhanced (myeloid DC, T-reg)

Cell line specificity

Low cell line specificity

Interaction

Homodimer of lamin A and lamin C. Interacts with lamin-associated polypeptides IA, IB and TMPO-alpha, RB1 and with emerin. Interacts with SREBF1, SREBF2, SUN2 and TMEM43. Interacts with TMEM201 (By similarity). Proteolytically processed isoform A interacts with NARF. Interacts with SUN1. Prelamin-A/C interacts with EMD. Interacts with MLIP. Interacts with DMPK; may regulate nuclear envelope stability. Interacts with SUV39H1; the interaction increases stability of SUV39H1. Interacts with SYNE2. Interacts with ITSN1 isoform 2 (PubMed:29599122). Interacts with IFFO1; enables the formation of an interior nucleoskeleton that is recruited to DNA double-strand breaks (PubMed:31548606). [Isoform C]: Interacts (via C-terminus) with LEMD2 (via N-terminus) (in vitro).

More Types Infomation