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LY9

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For Research Use Only. Not For Clinical Use.


Background

T-lymphocyte surface antigen Ly-9 is a protein that in humans is encoded by the LY9 gene.[5][6][7] LY9 has also recently been designated CD229 (cluster of differentiation 229)
Protein class

CD markers

Predicted location

Intracellular, Membrane (different isoforms)

Single cell type specificity

Cell type enhanced (B-cells, Plasma cells, Melanocytes, T-cells, dendritic cells)

Immune cell specificity

Group enriched (MAIT T-cell, gdT-cell, naive CD8 T-cell, memory CD8 T-cell, naive CD4 T-cell, memory CD4 T-cell, T-reg, plasmacytoid DC, memory B-cell, naive B-cell)

Cell line specificity

Cell line enhanced (Daudi, JURKAT, Karpas-707, U-266/70, U-266/84)

Interaction

Interacts with SH2D1A, SH2D1B and INPP5D. Interacts (via phosphorylated cytoplasmic domain) with PTPN11; the interaction is blocked by SH2D1A.

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