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MAP2K6
Anti-MAP2K6 Recombinant Antibody Products
- Recombinant Mouse Anti-Human MAP2K6 Antibody (MOB-1461MZ)
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- Species Reactivity: Human
- Type: Mouse antibody
- Application: WB
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- Mouse Anti-MAP2K6 Monoclonal Antibody (VS7-0425-WR341) (VS7-0425-WR341)
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- Species Reactivity: Human, Mouse
- Type: Mouse IgG
- Application: WB, IHC-P, IF, ELISA
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- Mouse Anti-MAP2K6 Monoclonal Antibody (VS7-0425-WR340) (VS7-0425-WR340)
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- Species Reactivity: Human, Mouse
- Type: Mouse IgG
- Application: WB, IF, ICC, FC, ELISA
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For Research Use Only. Not For Clinical Use.
This gene encodes a member of the dual specificity protein kinase family, which functions as a mitogen-activated protein (MAP) kinase kinase. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This protein phosphorylates and activates p38 MAP kinase in response to inflammatory cytokines or environmental stress. As an essential component of p38 MAP kinase mediated signal transduction pathway, this gene is involved in many cellular processes such as stress induced cell cycle arrest, transcription activation and apoptosis. [provided by RefSeq, Jul 2008]
Protein class
Enzymes, Metabolic proteins
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Glandular and luminal cells, Endometrial ciliated cells, Oligodendrocytes)
Immune cell specificity
Group enriched (plasmacytoid DC, neutrophil, classical monocyte)
Cell line specificity
Cell line enhanced (A549, AN3-CA, HUVEC TERT2, MOLT-4)
Interaction
Dimer. Interacts (via its D domain) with its substrates MAPK11, MAPK12, MAPK13 and MAPK14 (By similarity). Interacts (via its DVD domain) with MAP3Ks activators like MAP3K5/ASK1, MAP3K1/MEKK1, MAP3K2/MEKK2, MAP3K3/MEKK3, MAP3K4/MEKK4, MAP3K7/TAK1, MAP3K11/MLK3 and MAP3K17/TAOK2 (By similarity). Interacts with DCTN1. Interacts with EIF2AK2/PKR. (Microbial infection) Interacts with Yersinia YopJ.
Molecular function
Kinase, Serine/threonine-protein kinase, Transferase, Tyrosine-protein kinase
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