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MFN2
Anti-MFN2 Recombinant Antibody Products
- Rabbit Anti-MFN2 Polyclonal Antibody (MRO-2034-CN) (MRO-2034-CN)
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- Species Reactivity: Human, Rat
- Type: Rabbit IgG
- Application: WB, IF, FC
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- Mouse Anti-Mfn2 Recombinant Antibody (clone mN153/5.1) (VS-0422-LC146)
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- Species Reactivity: Mouse
- Type: Mouse IgG2a
- Application: ICC, WB, IF
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- Rabbit Anti-Mfn2 Recombinant Antibody (clone rN153/5.1) (VS-0422-LC147)
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- Species Reactivity: Mouse
- Type: Rabbit IgG
- Application: ICC, WB, IF
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- AbPlus™ Anti-MFN2 Magnetic Beads (VS-0724-YC638) (VS-0724-YC638)
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- Target: MFN2
- Target Species: Human
- Application: IP, Protein Purification
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- Anti-MFN2 Immunohistochemistry Kit (VS-0325-XY1344)
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- Species Reactivity: Human, Mouse, Rat
- Target: MFN2
- Application: IHC
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For Research Use Only. Not For Clinical Use.
This gene encodes a mitochondrial membrane protein that participates in mitochondrial fusion and contributes to the maintenance and operation of the mitochondrial network. This protein is involved in the regulation of vascular smooth muscle cell proliferation, and it may play a role in the pathophysiology of obesity. Mutations in this gene cause Charcot-Marie-Tooth disease type 2A2, and hereditary motor and sensory neuropathy VI, which are both disorders of the peripheral nervous system. Defects in this gene have also been associated with early-onset stroke. Two transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008]
Protein class
Disease related genes, Human disease related genes, Potential drug targets, Transporters
Predicted location
Intracellular, Membrane (different isoforms)
Single cell type specificity
Cell type enriched (Cardiomyocytes)
Immune cell specificity
Low immune cell specificity
Cell line specificity
Low cell line specificity
Interaction
Forms homomultimers and heteromultimers with MFN1 (PubMed:26085578). Oligomerization is essential for mitochondrion fusion (Probable). Interacts with VAT1 (By similarity). Interacts with STOML2; may form heterooligomers (PubMed:17121834). Interacts (phosphorylated) with PRKN (PubMed:23620051). Interacts with EIF2AK3 (By similarity). Interacts with THG1L; THG1L probably functions as a guanyl-nucleotide exchange factor/GEF, activating MFN2.
Molecular function
Hydrolase
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