MIP

Formats

Anti-MIP Recombinant Antibody Products

Mouse Anti-MIP Recombinant Antibody (clone 18D9) (MOB-3447z)
- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgM, κ
- Application: WB, IP, IF, ELISA
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For Research Use Only. Not For Clinical Use.

Major intrinsic protein is a member of the water-transporting aquaporins as well as the original member of the MIP family of channel proteins. The function of the fiber cell membrane protein encoded by this gene is undetermined, yet this protein is speculated to play a role in intracellular communication. The MIP protein is expressed in the ocular lens and is required for correct lens function. This gene has been mapped among aquaporins AQP2, AQP5, and AQP6, in a potential gene cluster at 12q13.

Protein class

Disease related genes, Human disease related genes

Predicted location

Membrane

Single cell type specificity

Cell type enhanced (Spermatocytes, Late spermatids, Early spermatids, Horizontal cells, Spermatogonia)

Immune cell specificity

Not detected in immune cells

Cell line specificity

Not detected

Interaction

Homotetramer (PubMed:24120416). Homooctamer formed by head-to-head interaction between homotetramers from adjoining membranes. Interacts with CALM; one CALM molecule interacts with the cytoplasmic domains of two aquaporins, leading to channel closure (By similarity). Interacts (via C-terminus) with BFSP1 (via C-terminus) in aged lens fiber cells (By similarity).

Molecular function

Eye lens protein

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