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MSP1

Anti-MSP1 Products
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- Derivation: Mouse
- Species Reactivity: P. falciparum
- Type: IgG
- Application: ELISA, WB, BL
- Mouse Anti-MSP1 Antibody (clone PEM-1), mRNA (MRO-014CT-mRNA)
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- Species Reactivity: Protozoan
- Mouse Anti-MSP1 Antibody (clone G17.12), mRNA (PABW-101-mRNA)
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- Species Reactivity: P. falciparum
- Human Anti-MSP1 Recombinant Antibody (clone D3) (VS-0423-XY19)
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- Species Reactivity: Plasmodium falciparum
- Type: Human IgG
- Application: ELISA, IF
- Human Anti-MSP1 Recombinant Antibody (clone C1) (VS-0423-XY20)
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- Species Reactivity: Plasmodium falciparum
- Type: Human IgG
- Application: ELISA, IF
- Human Anti-MSP1 Recombinant Antibody (clone D4) (VS-0423-XY21)
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- Species Reactivity: Plasmodium falciparum
- Type: Human IgG
- Application: ELISA, IF
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- Derivation: Mouse
- Species Reactivity: P. falciparum
- Type: IgG
- Application: ELISA, WB, BL
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- Derivation: Mouse
- Species Reactivity: P. falciparum
- Type: scFv
- Application: ELISA, WB, BL
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- Species Reactivity: Protozoan
- Application: ELISA, WB
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For Research Use Only. Not For Clinical Use.
Background
The merozoite surface protein 1 (MSP-1) is the most abundant protein on the surface of the erythrocyte-invading Plasmodium merozoite, the causative agent of malaria. MSP-1 is essential for merozoite formation, entry into and escape from erythrocytes, and is a promising vaccine candidate. Here, we present monomeric and dimeric structures of full-length MSP-1. MSP-1 adopts an unusual fold with a large central cavity. Its fold includes several coiled-coils and shows structural homology to proteins associated with membrane and cytoskeleton interactions. MSP-1 formed dimers through these domains in a concentration-dependent manner. Dimerization is affected by the presence of the erythrocyte cytoskeleton protein spectrin, which may compete for the dimerization interface. Our work provides structural insights into the possible mode of interaction of MSP-1 with erythrocytes and establishes a framework for future investigations into the role of MSP-1 in Plasmodium infection and immunity.
