


NFATC4

Anti-NFATC4 Products
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgM, κ
- Application: WB, ELISA, IF, IP
- Anti-NFATC4 Immunohistochemistry Kit (VS-0325-XY1490)
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- Species Reactivity: Human, Mouse, Rat
- Target: NFATC4
- Application: IHC
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For Research Use Only. Not For Clinical Use.
Background
Transcription factors
Intracellular
Cell type enhanced (Astrocytes, Endometrial stromal cells, Smooth muscle cells, Sertoli cells, Fibroblasts)
Not detected in immune cells
Cell line enhanced (ASC TERT1, BJ hTERT+, hTERT-RPE1)
Member of the multicomponent NFATC transcription complex that consists of at least two components, a pre-existing cytoplasmic component NFATC2 and an inducible nuclear component NFATC1. Other NFAT proteins, such as NFATC3, or members of the activating protein-1 (AP-1) family and MAF can also bind the complex. NFAT proteins can bind DNA as monomers or dimers (PubMed:7749981). Interacts with CREBBP; this interaction potentiates transcription activation (PubMed:11514544). Interacts with MAPK8/JNK1 and MAPK9/JNK2 (PubMed:17875713). Interacts with GATA4 (via the second Zn finger) (By similarity). Interacts (via N-terminus) with IRAK1 (via C-terminus) (PubMed:18691762). Interacts with RPS6KA3 (PubMed:17213202). Interacts with HOMER1, HOMER2 and HOMER3; this interaction competes with calcineurin/PPP3CA-binding and hence prevents NFATC4 dephosphorylation and activation (PubMed:18218901). Interacts with ESR1 and ESR2; this interaction decreases NFATC4 transcriptional activity (PubMed:18668201). Interacts with MTOR and MAPK7/ERK5 (PubMed:18347059). Interacts with TRIM17; this interaction prevents NFATC3 nuclear localization (By similarity).
Activator, Developmental protein, DNA-binding